Investigation for "intracellular obesity hypothesis" and its clinical application
| Project/Area Number |
23680069
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2011: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | インスリン抵抗性 / 異所性脂肪 / アルコール / 内臓脂肪 |
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| Research Abstract |
We investigated the cause of metabolic disorders in non-obese subjects, frequently seen in Asian people. We recruited 85 non-obese subjects and obese subjects with metabolic syndrome (n=14). We measured intramyocellular lipid (IMCL) and intrahepatic lipid (IHL). We also evaluated insulin sensitivity in muscle and liver by glucose clamp with stable isotope. Muscle insulin resistance was associated with higher TG and IHL and lower HDL-C levels. Multiple regression analysis revealed that maximum oxygen uptake, visceral fat volume and physical activity levels are recognized as independent determinant of muscle IR. In non-obese subjects, IRs in muscle and liver are independently occurred and physical activity may be important determinant of muscle IR.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] 非肥満者における、肝臓、骨格筋のインスリン抵抗性の臨床的意義とその原因探索2012
Author(s)
竹野景海,田村好史,川口美奈子,渡邉隆宏,船山崇,櫻井裕子,佐藤文彦,山本理紗子,金孟奎,筧佐織,池田真一,島田和典,藤谷与士夫,弘世貴久,代田浩之,河盛隆造,綿田裕孝
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
神奈川県(日本)
Related Report
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[Presentation] 非肥満者における、肝臓、骨格筋のインスリン抵抗性の臨床的意義とその原因探索2012
Author(s)
竹野景海,田村好史,川口美奈子,渡邉隆宏,船山崇,櫻井裕子,佐藤文彦,山本理紗子,金孟奎,筧佐織,池田真一,島田和典,藤谷与士夫,代田浩之,河盛隆造,綿田裕孝
Organizer
第33回日本肥満学会
Place of Presentation
京都府(日本)
Related Report
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