| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Research Abstract |
In this study, we attempted to understand the potential comprehensive relationship among a series of endogenous molecules with spatiotemporal information within tissue micro-regions for elucidating specific biological response to an orally dosed functional food factor. We succeeded in developing new techniques capable of two-dimensionally visualizing metabolome and proteome within tissue micro-regons, namely, multi-omics imaging, by improving a MALDI-MS technique. In addition, this analytical approach enabled us to simultaneously visualize orally dosed green tea catechin and metabolome within tissue micro-regions, and further visualized co-localization of green tea catechin and its target molecule. These results will provide a novel basic technology for understanding of precise food factor signaling response.
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