Innovative multi-molecular imaging strategy toward comprehensive understanding of food factor signaling response contributed to the health promotion
Project/Area Number |
23680073
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Eating habits, studies on eating habits
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Research Institution | Kyushu University |
Principal Investigator |
FUJIMURA Yoshinori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (20390304)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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Keywords | 質量分析イメージング / 食シグナル / メタボローム / プロテオーム / MALDI-MS / マルチオミクスイメージング |
Research Abstract |
In this study, we attempted to understand the potential comprehensive relationship among a series of endogenous molecules with spatiotemporal information within tissue micro-regions for elucidating specific biological response to an orally dosed functional food factor. We succeeded in developing new techniques capable of two-dimensionally visualizing metabolome and proteome within tissue micro-regons, namely, multi-omics imaging, by improving a MALDI-MS technique. In addition, this analytical approach enabled us to simultaneously visualize orally dosed green tea catechin and metabolome within tissue micro-regions, and further visualized co-localization of green tea catechin and its target molecule. These results will provide a novel basic technology for understanding of precise food factor signaling response.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] In situ label-free imaging for visulalization the biotransformation of a bioactive polyphenol2013
Author(s)
Kim Yoon Hee., Fujimura, Y., Hagihara, T., Sasaki, M., Yukihira, D., Nagao, T., Miura, D., Yamaguchi, S., Saito, K., Tanaka, H., wariishi, H., Yamada, K., and Tachibana, H
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Journal Title
Scientific Reports ジャーナル
Volume: 3巻
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ε germline transcription induced by STAT6 activation.2013
Author(s)
Kim Yoon Hee, Tanino, S., Fujimura, Y., Yamada, K., and Tachibana, H.
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Journal Title
FEBS Open Biologyジャーナル
Volume: 3巻
Issue: 1
Pages: 341-345
DOI
Related Report
Peer Reviewed
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[Presentation] 緑茶カテキンの組織内二次元分布情報を非標識可視化する質量分析イメージング法の開発2012
Author(s)
金允喜,藤村由紀,萩原立春,行平大地,山口歩,永尾達彦,齋藤和徳,三浦大典,割石博之,山田耕路,立花宏文
Organizer
第17回日本フードファクター学会学術集会および第9回日本カテキン学会合同大会
Place of Presentation
静岡市
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