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Database about circadian system regulating bioavailability of food factors, and their applications.

Research Project

Project/Area Number 23680074
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of Miyazaki (2012-2014)
University of Shizuoka (2011)

Principal Investigator

SAKAKIBARA Hiroyuki  宮崎大学, 農学部, 准教授 (20403701)

Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords体内時計 / 機能性成分 / 概日リズム / 生体内有効性 / マウス / 脂質代謝 / アントシアニン / 時間制限給餌 / 食品機能性成分 / 生物時計 / げっ歯類 / 培養細胞 / 食品機能成分 / 環境ストレス
Outline of Final Research Achievements

Circadian profiles, for example typical clock genes such as Bmal1, Clock and Cry, and transporter genes such as Sglt1, Pept1 and Mdr1, existing in the liver and small intestine were analyzed in mice. Following, database about circadian system regulating bioavailability of food factors were summarized. These circadian system including clock genes was affected by the environmental factors, for example nocturnal light and isolation stress exposure into mice. Furthermore, the effects of consumption timing at active- or inactive-phase on bioavailability of bilberry anthocyanins were evaluated. Their gastric emptying rate was significantly faster upon administration at the active-phase than that of the inactive-phase. Their amounts appeared in the plasma suggested also different time-dependent property, implying that the intensity of beneficial effects of anthocyanins might be different in the alimentary canal and/or physiological environment according to their consumption timing.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (30 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Invited: 8 results) Book (1 results)

  • [Journal Article] Practical application of flavonoid-poor menu meals to the study of the bioavailability of bilberry anthocyanins in human subjects2014

    • Author(s)
      Sakakibara H., Ichikawa Y., Yajima S., Makino Y., Wakasugi Y., Shimoi K., Kobayashi S., Kumazawa S., Goda T.
    • Journal Title

      Bioscience Biotechnology and Biochemistry

      Volume: 78 Issue: 10 Pages: 1748-1752

    • DOI

      10.1080/09168451.2014.932667

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nocturnal Light Exposure Alters Hepatic Pai-1 Expression by Stimulating the Adrenal Pathway in C3H Mice2014

    • Author(s)
      Aoshima Y., Sakakibara H., Suzuki T., Yamazaki S., Shimoi K.
    • Journal Title

      Experimental Animals

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 栄養素の消化・吸収機構に関与している体内時計2013

    • Author(s)
      榊原啓之、青島良輝、山崎隼輔、下位香代子
    • Journal Title

      New Food Industry

      Volume: 55 Pages: 1-8

    • NAID

      40019889489

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors2013

    • Author(s)
      Takashi Tsurusaki
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人の食事摂取基準(2005年版)に基づいたフラボノイド低減食の作成方法の提案2012

    • Author(s)
      榊原啓之
    • Journal Title

      日本栄養食糧学会誌

      Volume: 65 Pages: 129-135

    • NAID

      130002129277

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 外部刺激に対する生体応答を評価するために-夜行性のマウスを用いた時間生物学的アプローチ-2011

    • Author(s)
      榊原啓之, 小柳顯陽, 青島良輝, 鈴木敬明, 木村昌由美, 下位香代子
    • Journal Title

      谷本学校毒性質問箱

      Volume: 第13号 Pages: 116-123

    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of Consumption Timing on Bioavailability of Natural Pigments, Bilberry Anthocyanins2015

    • Author(s)
      Sakakibara H., Aoshima Y., Ogawa K., Kumazawa S., Shimoi K.
    • Organizer
      ICoFF2015
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2015-11-22 – 2015-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Effects of Consumption Timing on Gastric Emptying Time and Bioavailability of Whey Protein2015

    • Author(s)
      Sakakibara H., Nara T., Kato K., Sakono M.
    • Organizer
      ACN2015
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-05-14 – 2015-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 雌性C57BL/6マウスの血清および肝臓中脂質量の日内変動2015

    • Author(s)
      榊原 啓之、杉山 広、馬場 星吾、窄野 昌信
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体内時計が作り出す生体のリズム2014

    • Author(s)
      榊原啓之
    • Organizer
      第7回日本暖地畜産学会
    • Place of Presentation
      宮崎観光ホテル(宮崎県宮崎市)
    • Year and Date
      2014-10-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 単独隔離ストレスが血中コルチコステロンと時計遺伝子のリズムに与える影響2014

    • Author(s)
      榊原 啓之、青島 良輝、山崎 隼輔、下位 香代子
    • Organizer
      第37回 蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Place of Presentation
      レイクサイドホテル久山(福岡県糟屋郡)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] カフェインの新たな機能性の探索2014

    • Author(s)
      内之八重 勇光、窄野 昌信、榊原 啓之
    • Organizer
      第8回レドックス・ライフイノベーション 第170委員会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県宮崎市)
    • Year and Date
      2014-08-21 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 摂取時刻の違いが乳清タンパク質由来アミノ酸の吸収量に及ぼす影響2014

    • Author(s)
      津留崎 貴史、奈良 貴幸、加藤 健、窄野 昌信、榊原 啓之
    • Organizer
      2014年度生物機能研究会
    • Place of Presentation
      九州地区国立大学九重共同研修所(大分県玖珠郡)
    • Year and Date
      2014-07-12 – 2014-07-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of consumption timing on bioavailability of bilberry anthocyanins2013

    • Author(s)
      Sakakibara H., Aoshima Y., Yamazaki S., Tsurusaki T., Sakono M., Shimoi K
    • Organizer
      ICPH2013
    • Place of Presentation
      Argentina
    • Related Report
      2013 Annual Research Report
  • [Presentation] 外界からのストレス刺激がマウス肝臓中時計関連遺伝子の発現に与える影響2012

    • Author(s)
      青島良輝, 榊原啓之, 山崎隼輔, 鈴木敦美, 下位香代子
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都市、京都
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 機能性食品成分と生体イベントのクロノコミュニケーション2012

    • Author(s)
      榊原啓之, 青島良輝, 下位香代子
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都市、京都
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 体内時計が明らかにする未知なる世界2012

    • Author(s)
      榊原啓之
    • Organizer
      宮崎大学 オープンキャンパス 模擬講義
    • Place of Presentation
      宮崎大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 暗期の光曝露は副腎シグナル系を介して肝臓中のPai-1発現を上昇させる2011

    • Author(s)
      青島良輝, 榊原啓之, 鈴木敬明, 小柳顯陽, 山崎隼輔, 原のりこ, 下位香代子
    • Organizer
      第18回時間生物学会学術大会
    • Place of Presentation
      名古屋市、愛知
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食品成分が発揮する生体内有効性に生体リズムが与える影響2011

    • Author(s)
      青島良輝, 榊原啓之. 鈴木敬明, 小柳顯陽, 山崎隼輔, 原のりこ, 熊澤茂則, 下位香代子
    • Organizer
      環境科学講座「光と現代社会~電波から放射線まで、光利用とその影響についてもっと知ろう、学ぼう、そして考えよう~」
    • Place of Presentation
      静岡市、静岡県
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of flavonoid-poor diets considering dietary reference intakes and its application for bioavailability of bilberry anthocyanins in human subjects2011

    • Author(s)
      Sakakibara H., Ichikawa Y., Tajima S., Makino Y., Shimoi K.Wakasugi Y., Kobayashi S., Mochizuki K., Kumazawa S., Goda T.
    • Organizer
      5th International Conference on Polyphenols and Health
    • Place of Presentation
      Sitges, Barcelona, Spain
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食品成分が発揮する生体内有効性に生体リズムが与える影響2011

    • Author(s)
      青島良輝, 榊原啓之. 鈴木敬明, 小柳顯陽, 山崎隼輔, 原のりこ, 熊澤茂則, 下位香代子
    • Organizer
      フードサイエンスフォーラム第20回記念学術集会
    • Place of Presentation
      宮崎市、宮崎県
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食べる時間帯によって食品の機能性は異なるのか?~時間機能性食品学研究の最前線~

    • Author(s)
      榊原啓之
    • Organizer
      第23回西日本食品産業創造展'13
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 食品・栄養化学分野における〝時間〟の概念の重要性

    • Author(s)
      榊原啓之
    • Organizer
      第37回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Place of Presentation
      長崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of diurnal rhythmicity in biological processes on bioavailability of nutrients

    • Author(s)
      Sakakibara H.
    • Organizer
      第13回日伊科学技術宮崎国際会議2013 シンポジュウム&フォーラム
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 乳清タンパク質摂取後の血中アミノ酸量に及ぼす摂取時刻の影響

    • Author(s)
      津留崎貴史、青島良輝、奈良貴幸、加藤健、窄野昌信、下位香代子、榊原啓之
    • Organizer
      第18回日本フードファクター学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of consumption timing on gastric emptying time and bioavailability of bilberry anthocyanins

    • Author(s)
      Sakakibara H., Aoshima Y., Yamazaki S., Shimoi K
    • Organizer
      The 7th ASIAHORCs General Meeting and The 5th ASIAHORCs Joint Symposium
    • Place of Presentation
      インドネシア
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 農芸化学領域における時間機能性食品学

    • Author(s)
      榊原啓之
    • Organizer
      平成24年度日本農芸化学会西日本支部若手シンポジウム「農芸化学で斬り込む新領域」
    • Place of Presentation
      鹿児島大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 機能性食品研究に携わって17年目の挑戦-食品成分と体内リズムのクロノコミュニケーション-

    • Author(s)
      榊原啓之
    • Organizer
      金沢和樹先生退職記念講演会-食品・医薬品研究の最前線
    • Place of Presentation
      ANAクラウンホテル、神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 食べる時間帯によって食品の機能性は異なるのか?

    • Author(s)
      榊原啓之
    • Organizer
      第23回西日本食品産業創造展
    • Place of Presentation
      マリンメッセ福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 抗ストレス食品の動物による機能評価2011

    • Author(s)
      榊原啓之、下位香代子、寺尾純二
    • Publisher
      (株)シーエムシー出版
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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