Database about circadian system regulating bioavailability of food factors, and their applications.
| Project/Area Number |
23680074
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Miyazaki (2012-2014)
University of Shizuoka (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 体内時計 / 機能性成分 / 概日リズム / 生体内有効性 / マウス / 脂質代謝 / アントシアニン / 時間制限給餌 / 食品機能性成分 / 生物時計 / げっ歯類 / 培養細胞 / 食品機能成分 / 環境ストレス |
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| Outline of Final Research Achievements |
Circadian profiles, for example typical clock genes such as Bmal1, Clock and Cry, and transporter genes such as Sglt1, Pept1 and Mdr1, existing in the liver and small intestine were analyzed in mice. Following, database about circadian system regulating bioavailability of food factors were summarized. These circadian system including clock genes was affected by the environmental factors, for example nocturnal light and isolation stress exposure into mice. Furthermore, the effects of consumption timing at active- or inactive-phase on bioavailability of bilberry anthocyanins were evaluated. Their gastric emptying rate was significantly faster upon administration at the active-phase than that of the inactive-phase. Their amounts appeared in the plasma suggested also different time-dependent property, implying that the intensity of beneficial effects of anthocyanins might be different in the alimentary canal and/or physiological environment according to their consumption timing.
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Report
(5 results)
Research Products
(30 results)
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[Presentation] 食品成分が発揮する生体内有効性に生体リズムが与える影響2011
Author(s)
青島良輝, 榊原啓之. 鈴木敬明, 小柳顯陽, 山崎隼輔, 原のりこ, 熊澤茂則, 下位香代子
Organizer
環境科学講座「光と現代社会～電波から放射線まで、光利用とその影響についてもっと知ろう、学ぼう、そして考えよう～」
Place of Presentation
静岡市、静岡県
Year and Date
2011-11-09
Related Report
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[Presentation] Development of flavonoid-poor diets considering dietary reference intakes and its application for bioavailability of bilberry anthocyanins in human subjects2011
Author(s)
Sakakibara H., Ichikawa Y., Tajima S., Makino Y., Shimoi K.Wakasugi Y., Kobayashi S., Mochizuki K., Kumazawa S., Goda T.
Organizer
5th International Conference on Polyphenols and Health
Place of Presentation
Sitges, Barcelona, Spain
Year and Date
2011-10-19
Related Report
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