Roles of Notch signaling pathway in colon cancer metastasis

• Project/Area Number: 23680088
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: Kyoto University
• Principal Investigator: SONOSHITA Masahiro 京都大学, 大学院・医学研究科, 准教授 (80511857)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000); Fiscal Year 2012: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
• Keywords: 転移 / 遺伝子改変動物 / 大腸がん / Aes / Notch

Research Abstract

Cancer is the leading cause of death in most industrialized nations, and the direct cause of cancer death is often its metastasis to the vital organs. In this study, we demonstrate that Notch signaling regulates activities of Rho family small GTPases to stimulate invasion and metastasis of colon cancer. On the other hand, activation of PIK3CAin Apc mutant mice caused massive local invasion of intestinal tumors. These results raise novel therapeutic targets in invasion and metastasis of colon cancer.

Research Products

• [Journal Article] Molecular mechanisms of liver metastasis (2011)
  • Author(s): Kawada K, HaSegawa S, Murakami T, Itatani Y, Hosogi H, Sonoshita M, Kitamura T, Fujishita T, Iwamoto M, Matsumoto T, Matsusue R, Hida K, Akiyaraa G, Okoshi K, Yamada M, Kawamura J, Taketo MM, Sakai Y
  • Journal Title: Int J Clin Oncol Volume: 16 Issue: 5 Pages: 464-472
  • DOI: 10.1007/s10147-011-0307-2
  • NAID: 10030246531
  • Peer Reviewed
• [Presentation] Critical roles of Notch signaling pathway in colon cancer metastasis (2012)
  • Author(s): M. Sonoshita
  • Organizer: 国際がん転移学会
  • Place of Presentation: オーストラリア、ブリスベン
• [Presentation] Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling (2012)
  • Author(s): M. Sonoshita
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌市
• [Presentation] Stimulation of colon cancer metastasis by Notch signaling (2011)
  • Author(s): M. Sonoshita
  • Organizer: 第70回日本癌学会学術総会シンポジウム Use of animal models for advances in cancer prevention and treatment (英語)
  • Place of Presentation: 名古屋コングレスセンター
  • Year and Date: 2011-10-05
• [Presentation] Stimulation of colon cancer metastasis by Notch signaling (2011)
  • Author(s): M.Sonoshita
  • Organizer: 第70回日本癌学会学術総会シンポジウムUse of animal models for advances in cancer prevention and treatment(英語)
  • Place of Presentation: 名古屋コングレスセンター(招待講演)
  • Year and Date: 2011-10-05
• [Remarks] 京都大学大学院医学研究科遺伝薬理学教室ホームページ
  • URL: http://www4.mfour.med.kyoto-u.ac.jp/frameTOP(J).htm
• [Remarks] 京都大学大学院医学研究科遺伝薬理学教室ホームページ
  • URL: http://www4.mfour.med.kyoto-u.ac.jp/frameTOP(J).htm
• [Remarks]
  • URL: http://www4.mfour.med.kyoto-u.ac.jp/frameTOP(J).htm