Identification of in vitro reproductive toxicants in house and office environments
| Project/Area Number |
23681011
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
SUZUKI Go 独立行政法人国立環境研究所, 資源循環・廃棄物研究センター, 研究員 (70414373)
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| Research Collaborator |
KAWAGUCHI Maiko 明治大学, 農学部, 講師
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2012: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | ハウスダスト / 難燃剤 / バイオアッセイ / 化学物質リスク / 室内環境 / ARアンタゴニスト / ERαアゴニスト / PRアンタゴニスト / in vitroバイオアッセイ / 毒性同定評価 |
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| Research Abstract |
Indoor dust is a sink for many kinds of pollutants, including flame retardants (FRs). To reveal high-priority endpoints of and contaminant candidates in indoor dust, using reporter gene assays based on human U2OS cell lines, we characterized the endocrine-disrupting potencies of crude extracts of indoor dust collected from Japan and abroad and for 23 selected FRs. Indoor dust extracts were agonistic to ERa, GR, and PPARg2 and antagonistic against AR, PR, GR, and PPARg2. A majority of FRs was agonistic to ERa and PPARg2 only, and some FRs demonstrated antagonism against all tested nuclear receptors. Hierarchical clustering clearly indicated agonism of ERa and antagonism of AR and PR were common. Given our previous results regarding the concentrations of FRs in indoor dust and in light of our current results, candidate contributors to these effects includes FRs such TDCIPP. We have just started in vivo reproductive toxicity testing for TDCIPP by testing method established in this study.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Dioxin-related compounds in house dust from New York State : Occurrence, in vitro toxic evaluation and implications for indoor exposure2013
Author(s)
Tue, N.M., Suzuki, G., Takahashi, S., Kannan, K., Takigami, H., Tanabe, S.
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Journal Title
Environ. Poll.
Volume: 181
Pages: 75-80
DOI
Related Report
Peer Reviewed
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[Journal Article] Contamination of indoor dust and air by polychlorinated biphenyls and brominated flame retardants and relevance of non-dietary exposure in Vietnamese informal e-waste recycling sites2013
Author(s)
Tue, N.M., Takahashi, S., Suzuki, G., Isobe, T., Viet, P.H., Kobara, Y., Seike, N., Zhang, G., Sudaryanto, A., Tanabe, S.
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Journal Title
Environ. Int.
Volume: 51
Pages: 160-167
DOI
Related Report
Peer Reviewed
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[Journal Article] How Do Transport and Metabolism Affect on the Biological Effects of Polycyclic Aromatic Hydrocarbons?2012
Author(s)
Bekki, K., Toriba, A., Tang, N., Kameda, T., Takigami, H., Suzuki, G., Hayakawa, K.
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Journal Title
YAKUGAKU ZASSHI
Volume: 132
Issue: 3
Pages: 325-329
DOI
NAID
ISSN
0031-6903, 1347-5231
Year and Date
2012-03-01
Related Report
Peer Reviewed
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[Journal Article] Effect-based Approach for Hazard Identification of House Dust : Case Studies by Using In Vitro Bioassays Detecting Dioxin-like Compounds, Thyroid and Reproductive Toxicants
Author(s)
Suzuki, G., Tue, N.M., Takahashi, S., Tanabe, S., Sakai, S., Takigami, H.
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Journal Title
Curr. Org. Chem.
Volume: (Accepted)
Related Report
Peer Reviewed
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[Presentation] Antiandrogen during juvenile induce hypoplasia of penis and suppression of sexual behavior of male rats2013
Author(s)
Kamishima, M., Uemura, H., Horii, Y., Watanabe, G., Taya, K., Takigami, H., Suzuki, G., Kondo, Y., Kawaguchi, M.
Organizer
4th International NeuroMalaysia Symposium
Place of Presentation
Malaysia
Related Report
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[Presentation] Effects of antiandrogen on sexual behavior, organ weight and hormone levels of male rats2013
Author(s)
Kamishima, M., Uemura, H., Horii, Y., Watanabe, G., Taya, K., Harigaya, T., Takigami, H., Suzuki, G., Kondo, Y., Kawaguchi, M.
Organizer
The Endocrine Society's 95th Annual Meeting & Expo
Place of Presentation
U.S.A.
Related Report
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[Presentation] In vitro toxicological similarities between flame retardants and indoor dust collected from Japan, US, Vietnam, the Philippines, and Indonesia2012
Author(s)
Suzuki, G., Tue, N.M., Takahashi, S., Tanabe, S., Sakai, S., Malarvannan, G., Sudaryanto, A., Brouwer, A., Uramaru, N., Kitamura, S., Takigami, H.
Organizer
32th International Symposium on Halogenated Environmental Organic Pollutants and POPs
Place of Presentation
Cairns, Australia
Related Report
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[Presentation] レポーター遺伝子アッセイ/化学分析による毒性同定評価アプローチ高次野生生物への適用と評価2011
Author(s)
鈴木剛,滝上英孝,Nguyen Minh Tue,染矢雅之,高橋真,磯部友彦,田辺信介,Sander van der Linden,Bart van der Burg,Abraham Brouwer,Marja Lamoree,Martin van Velzen,山田格,田島木綿子
Organizer
第17回日本環境毒性学会・バイオアッセイ研究会合同発表会
Place of Presentation
鹿児島
Related Report
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