| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
Lipid nanotubes are nanoscale cylindrical objects formed with lipid bilayer membranes and have attracted remarkable attention due to their applications in biotechnology and nanotechnology. Biological lipid nanotubes, known as tunneling nanotubes, that connect biological cells over a long distance were recently investigated as a new cell-to-cell communication system. Here, novel methods were established to prepare tailor-made lipid nanotubes, which can be used to transport biological molecules and incorporate membrane proteins. By applying various external stimuli including electric and magnetic field to immobilized liposomes, we obtained long range membrane-bound lipid nanotubes arranged in a well-controlled direction. The lipid membrane engineering provides a novel and facile fabrication strategy for liposomal network array inter-connected via the lipid nanotubes.
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