Development of biofabrication techniques for living cells towards cell and tissue engineering
| Project/Area Number |
23681027
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Tohoku University |
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Principal Investigator |
KAJI Hirokazu 東北大学, 工学(系)研究科(研究院), 准教授 (70431525)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | バイオファブリケーション / 生体材料 / マイクロ・ナノデバイス / 細胞・組織 |
|---|
| Research Abstract |
Developing fabrication process under physiological conditions is of significance in order to utilize the maximum function of biosources such as proteins and living cells. In this project, biofabrication techniques to endure the fragility of living cells were developed towards in vitro cell and tissue engineering. The combination of microfluidic technique, soft lithographic technique, and surface engineering with hydrogels and polymeric nanosheets enabled the development of 2D and 3D cell culture systems capable of controlling cellular environments and it is demonstrated that these systems are useful for the formation of functional tissues including muscles.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] A Platform for Controlled Dual-Drug Delivery to the Retina : Protective Effects against Light-Induced Retinal Damage in Rats2014
Author(s)
N Nagai, H Kaji, H Onami, Y Katsukura, Y Ishikawa, ZK Nezhad, K Sampei, S Iwata, S Ito, M Nishizawa, T Nakazawa, N Osumi, Y Mashima, T Abe
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Journal Title
Advanced Healthcare Materials
Volume: in press
Issue: 10
Pages: 680-687
DOI
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Peer Reviewed / Open Access
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[Journal Article] Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films2014
Author(s)
Samad Ahadian, Javier Ramón-Azcón, Haixin Chang, Xiaobin Liang, Hirokazu Kaji, Hitoshi Shiku, Ken Nakajima, Murugan Ramalingam, Hongkai Wu, Tomokazu Matsue, Ali Khademhosseini
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Journal Title
RSC Advances
Volume: 4
Issue: 19
Pages: 9534-9541
DOI
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Peer Reviewed
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[Journal Article] Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells2012
Author(s)
Javier Ramón-Azcón, Samad Ahadian, Raquel Obregón, Gulden Camci-Unal, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue
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Journal Title
Lab Chip
Volume: 12
Issue: 16
Pages: 2959-2969
DOI
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Peer Reviewed
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[Book] "Bioinspired Muscle Tissue Devices" In Handbook of Biomimetics and Bioinspiration: 3 Volume Set, E. Jabbari, A. Khademhosseini, L. P. Lee, D.-H. Kim, A. Ghaemmaghami Eds.2014
Author(s)
Toshinori Fujie, Serge Ostrovidov, Samad Ahadian, S. Prakash Parthiban, Ali Khademhosseini, Hirokazu Kaji
Publisher
World Scientific Publishing
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[Book] MRS Symposium Proceesings Volume 1415, MEMS, BioMEMS and Bioelectronics – Materials and Devices, (pp. 1-221)2012
Author(s)
Tim Albrecht, Maarten P. de Boer, Frank W. DelRio, Mehmet R. Dokmeci, Cristoph Eberl, Junji Fukuda, Hirokazu Kaji, Chris Keimel, Ali Khademhosseini
Publisher
Cambridge University Press
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[Patent(Industrial Property Rights)] 細胞担持パターン化ナノ薄膜2013
Inventor(s)
梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
Industrial Property Rights Holder
梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
Industrial Property Rights Type
特許
Industrial Property Number
2013-137253
Filing Date
2013-06-28
Related Report
