| Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Outline of Final Research Achievements |
This study aimed to establish molecular and genetic technologies for investigating gene functions in the chordate Ciona intestinalis for elucidating mechanisms of the evolution of chordates. Through transposon-mediated transgenesis and gene knockouts, this study revealed functions of various genes that are conserved among chordates in this ascidian. Hox10 is essential for forming the intestine by regulating the migration of endodermal cells. Gonadotropin-releasing hormones expressed at the larval stage are involved in the regulation of metamorphosis of Ciona. New mechanisms of cell cycle regulation has been revealed that are mediated by conserved, developmentally relevant transcription factors. These new findings provide us new insights for deepen the knowledge about the evolution of chordates and ascidians.
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