Controlling cell function by synthetic biology approaches
| Project/Area Number |
23681042
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
System genome science
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| Research Institution | Kyoto University |
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Principal Investigator |
SAITO Hirohide 京都大学, 白眉センター, 准教授 (20423014)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2012: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 合成生物学 / RNA / 翻訳 / RNP / バイオエンジニアリング / 遺伝子回路 / 細胞分化 / 遺伝子スイッチ / 遺伝子発現制御 |
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| Research Abstract |
It is important to develop a method that controls gene expression dependent on intracellular environment.In synthetic biology field, researchers aim to understand life and develop new biotechnologies through the process of designing and constructing biomolecules and biological systems. However, designing functional biomolecules and systems to control cell function has remained a challenge. In this study, we designed synthetic "RNA switches" that detect specific proteins expressed in cells and control expression of target genes. As a result, we generated several RNA switches that function in mammalian cells (Nucleic Acids Res. 40:9369, 2012, Nucleic Acids Res. 41:e135, 2013, Nature Commun. 4:2393,2013).
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Report
(4 results)
Research Products
(107 results)
