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Unified Total Synthesis and Structure-Activity Relationships of Marine Macrolide Natural Products of Cyanobacteria Origin

Research Project

Project/Area Number 23681045
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionTohoku University

Principal Investigator

FUWA Haruhiko  東北大学, 生命科学研究科, 准教授 (90359638)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywords海洋天然物 / 全合成 / 構造活性相関 / 生物活性分子の設計 / 細胞増殖阻害 / ミトコンドリア / 作用解析 / 抗がん作用 / マクロリド
Research Abstract

This project pursued unified total synthesis and structure-activity relationships of marine macrolide natural products of cyanobateria origin. Our concise synthesis of neopeltolide, a highly potent antiproliferative macrolide, enabled us to elucidate its pharmacophoric structural elements required for potent activity. Several truncated neopeltolide analogues with nanomolar activity were successfully designed on the basis of our pharmacophore model. Concise total synthesis of lyngbyaloside B, a moderately cytotoxic macrolide glycoside, and its 13-demethyl analogue was also achieved. Design, synthesis, and biological evaluation of chimeric macrolides were undertaken to show that polyketide macrolides offer unique structural motifs useful for the development of novel antiproliferative agents.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (74 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results,  Acknowledgement Compliant: 2 results) Presentation (43 results) (of which Invited: 3 results) Remarks (3 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 4 results)

  • [Journal Article] Stereoselective synthesis of medium-sized cyclic ethers: Application of C-glycosylation chemistry to seven- to nine-membered lactone-derived thioacetals and their sulfone counterparts2014

    • Author(s)
      Yuto Suga, Haruhiko Fuwa, Makoto Sasaki
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 79 Issue: 4 Pages: 1656-1682

    • DOI

      10.1021/jo4025545

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total synthesis and structure revision of didemnaketal B2014

    • Author(s)
      Haruhiko Fuwa, Takashi Muto, Kumiko Sekine, Makoto Sasaki
    • Journal Title

      Chemistry A European Journal

      Volume: 20 Issue: 7 Pages: 1848-1860

    • DOI

      10.1002/chem.201303713

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total synthesis of the proposed structure of didemnaketal B2013

    • Author(s)
      Haruhiko Fuwa, Kumiko Sekine, Makoto Sasaki
    • Journal Title

      Organic Letters

      Volume: 15 Issue: 15 Pages: 3970-3973

    • DOI

      10.1021/ol4017518

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of aspergillide A/neopeltolide chimeras2013

    • Author(s)
      H. Fuwa, K. Noto, M. Kawakami, M. Sasaki
    • Journal Title

      Chem. Lett

      Volume: 42

    • NAID

      10031194327

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements2013

    • Author(s)
      H. Fuwa, M. Kawakami, K. Noto, T. Muto, Y. Suga, K. Konoki, M. Yotsu-Yamashita, and M. Sasaki
    • Journal Title

      Chem. Eur.J.

      Volume: 19 Issue: 25 Pages: 8100-8110

    • DOI

      10.1002/chem.201300664

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis and biological evaluation of (-)-exiguolide analogues: Importance of the macrocyclic backbone2013

    • Author(s)
      Haruhiko Fuwa, Kana Mizunuma, Makoto Sasaki, Takaya Suzuki, Hiroshi Kubo
    • Journal Title

      Organic & Bimolecular Chemistry

      Volume: 11 Issue: 21 Pages: 3442-3450

    • DOI

      10.1039/c3ob40131f

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of 13-demethyllyngbyaloside B2013

    • Author(s)
      H. Fuwa, N. Yamagata, A. Saito, M. Sasaki
    • Journal Title

      Org. Lett

      Volume: 15 Issue: 7 Pages: 1630-1633

    • DOI

      10.1021/ol400408w

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis and biological evaluation of(+)-gambieric acid A and its analogues.2013

    • Author(s)
      K. Ishigai, H. Fuwa, K. Hashizume, R. Fukazawa, Y. Cho, M. Yotsu-Yamashita, and M. Sasaki
    • Journal Title

      Chemistry-A European Journal

      Volume: 19 Issue: 17 Pages: 5276-5288

    • DOI

      10.1002/chem.201204303

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of tetrahydropyran-containing natural products exploiting intramolecular oxa-conjugate cyclization2012

    • Author(s)
      H. Fuwa
    • Journal Title

      Heterocycles

      Volume: 85 (Invited personal account) Issue: 6 Pages: 1255-1298

    • DOI

      10.3987/rev-12-730

    • NAID

      40019281365

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of gambierol and its heptacylic and tetracyclic analogues in cultured cerebellar neurons. A structure–activity relationships study2012

    • Author(s)
      S. Perez, C. Vale, E. Alonso, H. Fuwa, M. Sasaki, Y. Konno, T. Goto, Y. Suga, M. R. Vieytes, L. M. Botana
    • Journal Title

      Chem. Res. Toxicol

      Volume: 25 Issue: 9 Pages: 1929-1937

    • DOI

      10.1021/tx300242m

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization : Concise synthesis of 2,6-cis-substituted tetrahydroyran derivatives2012

    • Author(s)
      H. Fuwa T. Noguchi, K. Noto, M. Sasaki
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Issue: 40 Pages: 8108-8112

    • DOI

      10.1039/c2ob26189h

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis and complete stereostructure of gambieric acid A.2012

    • Author(s)
      H. Fuwa, K, Ishigai, K. Hashizume, and M. Sasaki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 134 Issue: 29 Pages: 11984-11987

    • DOI

      10.1021/ja305864z

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A concise synthesis of the AB-ring fragment of (−)-gambierol2012

    • Author(s)
      H. Fuwa, K. Hirota, M. Sasaki
    • Journal Title

      Heterocycles

      Volume: 86 Issue: 1 Pages: 127-132

    • DOI

      10.3987/com-12-s(n)21

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective synthesis of the C1–C16 fragment of goniodomin A2012

    • Author(s)
      M. Nakajima, H. Fuwa, M. Sasaki
    • Journal Title

      Bull. Chem. Soc. Jpn

      Volume: 85 (BCSJ Selected Paper) Issue: 9 Pages: 948-956

    • DOI

      10.1246/bcsj.20120152

    • NAID

      130004153113

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of skeletal analogues of gambierol : Attenuation of amyloid-βand tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications2012

    • Author(s)
      E. Alonso, H. Fuwa, C. Vale, Y. Suga, T. Goto, Y. Konno, M. Sasaki, F. M. LaFerla, M. R. Vieytes, L. Gimenez-Llort, L. M. Botana
    • Journal Title

      J. Am. Chem. Soc

      Volume: 134 Issue: 17 Pages: 7467-7479

    • DOI

      10.1021/ja300565t

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective synthesis of 2,6-cis-substituted tetrahydropyrans : Bronsted acid-catalyzed intramolecular oxa-conjugate cyclization of α,β-unsaturated ester surrogates2012

    • Author(s)
      H.Fuwa, N.Ichinokawa, K.Noto, M.Sasaki
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 77 Issue: 6 Pages: 2558-2607

    • DOI

      10.1021/jo202179s

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent Applications of the Suzuki-Miyaura Cross-coupling to Complex Polycyclic Ether Synthesis2011

    • Author(s)
      H. Fuwa, M. Ebine, M. Sasaki
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 69 Issue: 11 Pages: 1251-1262

    • DOI

      10.5059/yukigoseikyokaishi.69.1251

    • NAID

      10029927949

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of (-)-brevenal : A streamlined strategy for practical synthesis of polycyclic ethers2011

    • Author(s)
      M.Ebine, H.Fuwa, M.Sasaki
    • Journal Title

      Chemistry A European Journal

      Volume: 17 Issue: 49 Pages: 13754-13761

    • DOI

      10.1002/chem.201101437

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative cytotoxicity of gambierol versus other marine neurotoxins2011

    • Author(s)
      E.Cagide, M.C.Louzao, B.Espina, I.R.Ares, M.R.Vieytes, M.Sasaki, H.Fuwa, M.Yotsu-Yamashita, L.A.Paquette, T.Yasumoto, L.M.Botana
    • Journal Title

      Chemical Research in Toxicology

      Volume: 24 Issue: 6 Pages: 835-842

    • DOI

      10.1021/tx200038j

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers : convergent synthesis of a fully elaborated GHIJ-ring fragment2011

    • Author(s)
      K.Tsubone, K.Hashizume, H.Fuwa, M.Sasaki
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 35 Pages: 6600-6615

    • DOI

      10.1016/j.tet.2011.05.082

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrons via palladium-catalyzed coupling of thioesters2011

    • Author(s)
      H.Fuwa, K.Mizunuma, S.Matsukida, M.Sasaki
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 27-28 Pages: 4995-5010

    • DOI

      10.1016/j.tet.2011.03.114

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis-inspired intramolecular oxa-conjugate cyclization of α,β-unsaturated thioesters : Stereoselective Synthesis of 2,6-cis-substituted tetrahydropyrans2011

    • Author(s)
      H.Fuwa, K.Noto, M.Sasaki
    • Journal Title

      Organic Letters

      Volume: 13 Issue: 7 Pages: 1820-1823

    • DOI

      10.1021/ol200333p

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent applications of the Suzuki-Miyaura cross-coupling to complex polycyclic ether synthesis2011

    • Author(s)
      H. Fuwa, M. Ebine, *M. Sasaki
    • Journal Title

      J. Syn. Org. Chem. Jpn.(有機合成化学協会誌)

      Volume: 69 Pages: 1251-1262

    • NAID

      10029927949

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ネオペルトリド類縁体の作用解析研究2014

    • Author(s)
      佐藤みずほ,不破春彦,佐々木誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ネオペルトリドの構造活性相関研究 : オキサゾール含有側鎖の重要性2014

    • Author(s)
      野口拓真,川上雅人,不破春彦,佐々木誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] リングビヤロシドBの全合成研究2014

    • Author(s)
      奥秋佑太,不破春彦,佐々木誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 30-デメチルガンビエル酸Aの合成研究2014

    • Author(s)
      深澤 亮,不破春彦,佐々木 誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 光親和性標識基を導入したガンビエロール単純化類縁体の合成と生物活性評価2014

    • Author(s)
      廣田一晃,菅 悠人,此木敬一,山下まり,不破春彦,佐々木 誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] アンフィジノリドNの全合成研究2014

    • Author(s)
      川島悠岐,豊島惇,不破春彦,佐々木 誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] イリオモテオリド-2aの全合成研究2014

    • Author(s)
      袴田旺弘,不破春彦,佐々木 誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] リングビアロシドBの全合成研究2014

    • Author(s)
      奥秋佑太,不破春彦,佐々木 誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] ネオペルトリドの構造活性相関研究:オキサゾール含有側鎖の重要性2014

    • Author(s)
      野口拓真,川上雅人,不破春彦,佐々木 誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Studies toward the total synthesis of iriomoteolide-2a (poster presentation)2013

    • Author(s)
      H. Fuwa
    • Organizer
      The 2nd International Symposium on Chemical Biology of Natural Products : Target ID and Regulation of Bioactivity
    • Place of Presentation
      Yokohama
    • Year and Date
      2013-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Total synthesis and biological evaluation of marine macrolide natural products2013

    • Author(s)
      H. Fuwa
    • Organizer
      International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2013-09-29
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ディデムナケタールBの全合成と完全立体構造決定2013

    • Author(s)
      武藤崇史,関根久美子,不破春彦,佐々木誠
    • Organizer
      第104回有機合成シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ディデムナケタールBの全合成と完全立体構造決定2013

    • Author(s)
      武藤崇史,関根久美子,不破春彦,佐々木誠
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 海洋天然物の効率的全合成と高活性構造単純化類縁体の創出2013

    • Author(s)
      不破春彦
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー : 分子標的と活性制御」第四回領域公開シンポジウム
    • Place of Presentation
      つくば
    • Related Report
      2013 Final Research Report
  • [Presentation] ネオペルトリド構造類縁体の設計・合成・活性評価2013

    • Author(s)
      川上雅人,武藤崇史,不破春彦,佐々木誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] リングビヤロシドB類縁体の合成と活性評価2013

    • Author(s)
      山縣直哉,不破春彦,佐々木誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Final Research Report
  • [Presentation] タンデム反応によるテトラヒドロピラン誘導体の合成2013

    • Author(s)
      野口拓真,能登健吉,不破春彦,佐々木誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] ディデムナケタールBの全合成と完全立体構造決定2013

    • Author(s)
      武藤崇史,関根久美子,不破春彦,佐々木 誠
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ディデムナケタールBの全合成と完全立体構造決定2013

    • Author(s)
      武藤崇史,関根久美子,不破春彦,佐々木 誠
    • Organizer
      第104回有機合成シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海洋天然物の効率的全合成と高活性構造単純化類縁体の創出2013

    • Author(s)
      不破春彦
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第四回領域公開シンポジウム
    • Place of Presentation
      つくば
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ディデムナケタールBの全合成研究:提出構造式の全合成2013

    • Author(s)
      関根久美子,不破春彦,佐々木 誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゴニオドミンAの全合成研究2013

    • Author(s)
      中島基博,不破春彦,佐々木 誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] オカダ酸の全合成研究2013

    • Author(s)
      武藤崇史,不破春彦,佐々木 誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] ガンビエル酸Aおよび類縁体の合成と生物活性評価2013

    • Author(s)
      石貝和也,深澤 亮,不破春彦,佐々木 誠,長 由扶子,山下まり
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] 混合チオアセタールの官能基化による環状エーテル合成2013

    • Author(s)
      菅 悠人,不破春彦,佐々木 誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] イリオモテオリド-2aの全合成研究2013

    • Author(s)
      市野川直輝,不破春彦,佐々木 誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] リングビアロシドB類縁体の合成と活性評価2013

    • Author(s)
      山縣直哉、不破春彦、佐々木 誠
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] イグジグオリド類縁体の合成と活性評価2013

    • Author(s)
      水沼佳奈,不破春彦,佐々木 誠,鈴木隆哉,久保裕司
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] Total synthesis and structure–activity relationships of marine macrolides and their analogues2012

    • Author(s)
      H. Fuwa
    • Organizer
      The 1st International Symposium on Chemical Biology of Natural Products : Target ID and Regulation of Bioactivity
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-10-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 海洋天然物イグジグオリドの化学合成と抗腫瘍活性評価2012

    • Author(s)
      不破春彦
    • Organizer
      東北大学イノベーションフェア2012
    • Place of Presentation
      東京
    • Year and Date
      2012-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ガンビエル酸Aの全合成2012

    • Author(s)
      石貝和也,橋詰圭祐,不破春彦,佐々木誠
    • Organizer
      第102回有機合成シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] ガンビエル酸Aの全合成と完全立体構造決定2012

    • Author(s)
      不破春彦,石貝和也,橋詰圭祐,佐々木誠
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] ガンビエロール構造単純化類縁体の設計・合成・評価2012

    • Author(s)
      菅悠人,不破春彦,後藤智見,今野悠,佐々木誠,Eva Alonso,Carmen Vale,Luis M. Botana
    • Organizer
      第7回日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] ネオペルトリドの効率的全合成と立体構造活性相関2012

    • Author(s)
      川上雅人,能登健吉,斎藤麻美,菅悠人,不破春彦,佐々木誠
    • Organizer
      第101回有機合成シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 13-デメチルリングビヤロシドBの合成研究2012

    • Author(s)
      山縣直哉,不破春彦,佐々木誠
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] ネオペルトリドの効率的全合成と構造類縁体ライブラリーの構築2012

    • Author(s)
      能登健吉,川上雅人,斎藤麻美,菅悠人,不破春彦,佐々木誠
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] ガンビエル酸Aの全合成研究2012

    • Author(s)
      石貝和也,橋詰圭祐,不破春彦,佐々木誠
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] ガンビエロールの構造単純化類縁体の設計・合成・評価2012

    • Author(s)
      菅 悠人,不破春彦,後藤智見,今野 悠,佐々木 誠,Eva Alonso, Carmen Vale, Luis M. Botana
    • Organizer
      第7回日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] ガンビエロールの構造単純化類縁体の合成と生物活性評価2012

    • Author(s)
      菅 悠人,不破春彦,後藤智見,今野 悠,佐々木 誠,Eva Alonso, Carmen Vale, Luis M. Botana
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海洋天然物(−)-exiguolideの全合成と生物活性評価2011

    • Author(s)
      不破春彦
    • Organizer
      第10回化学系薬学若手研究者のセミナー
    • Place of Presentation
      仙台
    • Year and Date
      2011-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 微量複雑海洋天然物の全合成とケミカルバイオロジーへの展開2011

    • Author(s)
      不破春彦
    • Organizer
      東北大学グローバルCOEプログラム分子系高次構造体化学国際教育研究拠点シンポジウム2011
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 海洋天然物(-)-exiguolideの全合成と生物活性評価2011

    • Author(s)
      不破 春彦
    • Organizer
      第10回化学系薬学若手研究者のセミナー
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 微量複雑海洋天然物の全合成とケミカルバイオロジーへの展開2011

    • Author(s)
      不破 春彦
    • Organizer
      東北大学GCOEプログラム分子系高次構造体化学国際教育研究拠点シンポジウム2011
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/kanshoku/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] Sasaki Research Group, Tohoku University

    • URL

      http://www.agri.tohoku.ac.jp/kanshoku/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] Sasaki Research Group, Tohoku University

    • URL

      http://www.agri.tohoku.ac.jp/kanshoku/index.html

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗がん作用を有する複素環化合物2012

    • Inventor(s)
      不破春彦,佐々木誠
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-235042
    • Filing Date
      2012-10-24
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗がん作用を有する複素環化合物2012

    • Inventor(s)
      不破春彦,佐々木 誠
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-235042
    • Filing Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗がん作用を有するマクロライド 化合物2011

    • Inventor(s)
      不破春彦,佐々木誠,久保裕司,鈴木隆哉
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-10-28
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ポリ環状エーテル化合物によるタウ蛋白とアミロイドβに関連する神経変性疾患の治療および予防2011

    • Inventor(s)
      L. M. Botanaら
    • Industrial Property Rights Holder
      サンティアゴ大学,国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗がん作用を有するマクロライド化合物2011

    • Inventor(s)
      不破春彦,佐々木誠,鈴木隆哉,久保裕司
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
    • Overseas

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Published: 2011-04-06   Modified: 2019-07-29  

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