|Budget Amount *help
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|Outline of Final Research Achievements
Serotonin in the brain has been strongly implicated in the neural mechanism of escalated aggression. However, how the activity of serotonergic system is regulated or what kind of neural input modulate serotonergic system during aggressive behavior is still not clear. In this study, we aimed to manipulate the activity of serotonergic system in the dorsal raphe nucleus (DRN) during the aggressive encounter of male mice by using optogenetics, and examined its role on aggressive behavior. Also, we aimed to identify neural input into the DRN during aggressive behavior, and we found that the glutamatergic input into the DRN determines the level of aggression in male mice. We also conducted forward genetics analysis to map genetic loci involved in escalated aggression of male mice by using consomic mouse strain of MSM/Ms and C57BL/6J.