Detection and control of molecular orientation and reactivity of biomembrane model reaction field including proteins
| Project/Area Number |
23685003
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical chemistry
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
TERO Ryugo 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (40390679)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 表面・界面 / 界面物理化学 / 脂質二重膜 / 原子間力顕微鏡 / 蛍光一分子観察 / 1分子計測 / 脂質 / 表面・界面物性 / 一分子計測 |
|---|
| Research Abstract |
I constructed a new biomembranes model system for the investigation of the active structures of lipid molecules which act as reactive factors of membrane proteins at cell membrane reactions. I fabricated a supported lipid bilayer (SLB) including phosphatidylinositol on mica substrate, and found that depression domains with 20 - 300 nm in lateral size and ~0.9 nm in depth in the PI-SLB. In-situ atomic force microscope (AFM) observation revealed that these submicron depression domains acted as the nucleation site of the self-assembly of F-BAR on the PI-SLB, a membrane deformation protein, and the surrounding region of the depression domains provided the F-BAR to the nucleation site. It is a novel result clearly showing the roles of submicron lipid domains during a protein reaction. I also established the fabrication methods of SLBs on graphene oxide and poly vinyl chloride membrane for the development of the methods to evaluate the molecular state and membrane properties in the SLBs.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Ecofriendly Route for the Synthesis of Highly Conductive Graphene Using Extremophiles for Green Electronics and Bioscience2013
Author(s)
S. Raveendran, N. Chauhan, Y. Nakajima, H. Toshiaki, S. Kurosu, Y. Tanizawa, R. Tero, Y. Yoshida, T. Hanajiri, T. Maekawa, P. M. Ajayan, A. Sandhu and D. S. Kumar
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Journal Title
Part. Part. Syst. Charact
Volume: 30
Issue: 7
Pages: 573-578
DOI
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Peer Reviewed
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[Presentation] グラフェン酸化物上への細胞膜モデル系の作製とその観察
Author(s)
手老 龍吾, 岡本 吉晃, ムアザム シャー ビン マット ノール, 岩佐 精二, サンドゥー アダルシュ
Organizer
応用物理学会有機分子・バイオエレクトロニクス分科会研究会「有機分子・バイオエレクトロニクスの新たな挑戦」
Place of Presentation
新潟・新潟大学駅南キャンパス
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[Book] Reviews in Plasmonics 2010, Chapter 5, "Fabrication and Application of Plasmonic Silver Nanosheet"2012
Author(s)
K.Tamada,X.Li, P.Wulandari, T.Nagahiro, K.Michioka, M.Toma, K.Toma, D.Obara, T.Nakada, T.Hayashi, Y.Ikezoe, M.Hara, S.Katano, Y.Uehara, Y.Kimura, M.Niwano, R.Tero, K.Okamoto
Publisher
Springer
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[Book] "Fabrication and Application of Plasmonic Silver Nanosheet", in Reviews in Plasmonics 2010, edited by C. D. Geddes2011
Author(s)
K. Tamada, X. Li, P. Wulandari, T. Nagahiro, K. Michioka, M. Toma, K. Toma, D. Obara, T. Nakada, T. Hayashi, Y. Ikezoe, M. Hara, S. Katano, Y. Uehara, Y. Kimura, M. Niwano, R. Te ro and K. Okamoto
Publisher
Springer
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