Activation of chemical bonds between main-elements in body by multifunctional copper catalysts
| Project/Area Number |
23685008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAMURA Itaru 東北大学, 理学(系)研究科(研究院), 准教授 (00333899)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 結合活性化 / 銅触媒 / ヘテロ環 / 転位反応 / ドミノ反応 / 効率的合成 / 環境調和型分子変換 / 触媒反応 / 骨格転位 / 結合切断 / ロジウム触媒 / 水溶性配位子 / 不斉転写 |
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| Outline of Final Research Achievements |
In this investigation, we developed several synthetic reactions involving cleavage of sigma bonds between "main elements in body" by the use of multi-functional copper catalysts. In particular, we developed skeletal rearrangement and cascade reactions employing O-propargylic oximes as the substrate. These reaction involves cleavage of C-O and/or N-O bonds. Copper catalysts consecutively functioned not only pi-activation catalyst but also sigma acids and single-electron transfer catalysts. Moveover, our investigations realized efficient synthesis of new class of heterocyclic compounds, such as four-membered cyclic nitrones, pyridine-N-oxides, dihydropyrimidines, triazines, and oxazepines.
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Report
(4 results)
Research Products
(31 results)
