| Budget Amount *help |
¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Outline of Final Research Achievements |
In this investigation, we developed several synthetic reactions involving cleavage of sigma bonds between "main elements in body" by the use of multi-functional copper catalysts. In particular, we developed skeletal rearrangement and cascade reactions employing O-propargylic oximes as the substrate. These reaction involves cleavage of C-O and/or N-O bonds. Copper catalysts consecutively functioned not only pi-activation catalyst but also sigma acids and single-electron transfer catalysts. Moveover, our investigations realized efficient synthesis of new class of heterocyclic compounds, such as four-membered cyclic nitrones, pyridine-N-oxides, dihydropyrimidines, triazines, and oxazepines.
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