| Budget Amount *help |
¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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| Outline of Final Research Achievements |
We have developed the highly sensitive method to recognize a small chirality by using asymmetric autocatalysis. It has been demonstrated that asymmetric autocatalysis could discriminate an extremely small difference between the enantiomers arising from oxygen-isotope substitution.
Moreover, chiral crystals of achiral nucleobase cytosine and adenine, and triester can be discriminated by asymmetric autocatalysis with amplification of ee. A chiral mineral, cinnabar, served as a chiral source of asymmetric autocatalysis to afford enantioenriched 5-pyrimidyl alkanol. The adsorption structures of related compounds were observed with atomic force microscopy.
The oriented prochirality, i.e., two-dimensional chirality at the surface of achiral single crystal could also be discriminated by asymmetric autocatalysis to afford enantioenriched alkanol with high ee. The absolute configuration of the alkanol correlated with the chirality at the crystal surface.
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