| Budget Amount *help |
¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
1-Sulfonyl-1,2,3-triazoles, which can be easily prepared from terminal alkynes by the copper-catalyzed 1,3-dipolar cycloaddition reaction with N-sulfonyl azides, have recently received much attention as precursors of carbenoid species. Their ring-chain tautomerization forms alpha-diazo imines, which react with transition-metal complexes to generate the corresponding alpha-imino metal carbenes. We have developed various types of new transformations starting from terminal alkynes via alpha-imino metal carbenes. These methods provide a highly step-economical route to complex molecules (N-containing heterocycles) in one pot.
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