Synthesis of N-Containing Heterocycles Based on the Invention of Azametallacycles
Project/Area Number |
23685019
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Synthetic chemistry
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Research Institution | Kyoto University |
Principal Investigator |
MIURA Tomoya 京都大学, 工学(系)研究科(研究院), 准教授 (10378804)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 選択的合成 / 環境調和型反応 / 含窒素へテロ環化合物 / ロジウム / 触媒反応 / 有機化学 / 合成化学 / アザメタラサイクル / ヘテロ環合成 / ニッケル / 不斉反応 |
Research Abstract |
1-Sulfonyl-1,2,3-triazoles, which can be easily prepared from terminal alkynes by the copper-catalyzed 1,3-dipolar cycloaddition reaction with N-sulfonyl azides, have recently received much attention as precursors of carbenoid species. Their ring-chain tautomerization forms alpha-diazo imines, which react with transition-metal complexes to generate the corresponding alpha-imino metal carbenes. We have developed various types of new transformations starting from terminal alkynes via alpha-imino metal carbenes. These methods provide a highly step-economical route to complex molecules (N-containing heterocycles) in one pot.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Stereoselective Synthesis of 2,3-Dihydropyrroles from Terminal Alkynes, Azides, and α,β-Unsaturated Aldehydes via N-Sulfonyl-1,2,3-triazoles2013
Author(s)
Tomoya Miura, Takamasa Tanaka, Kentaro Hiraga, Scott G. Stewart, Masahiro Murakami
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Journal Title
J . Am. Chem. Soc
Volume: 135
Pages: 13652-13655
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[Journal Article] Stereoselective Synthesis of 2,3-Dihydropyrroles from Terminal Alkynes, Azides, and α,β-Unsaturated Aldehydes via N-Sulfonyl-1,2,3-triazoles2013
Author(s)
Tomoya Miura, Takamasa Tanaka, Kentaro Hiraga, Scott G. Stewart, and Masahiro Murakami
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Journal Title
Journal of the American Chemical Society
Volume: 135
Issue: 37
Pages: 13652-13655
DOI
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Peer Reviewed
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[Presentation] Stereoselective Synthesis of 2,3-Dihydropyrroles from Terminal Alkynes, Azides, and α,β-Unsaturated Aldehydes via N-Sulfonyl-1,2,3-triazoles2013
Author(s)
Tomoya Miura,Takamasa Tanaka, Kentaro Hiraga, Scott G.Stewart, Masahiro Murakami
Organizer
The Eighth International Symposium on Integrated Synthesis (ISIS-8)
Place of Presentation
奈良 (ポスター発表)
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