| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
The glycopolymers having sulfonated N-acetyl glucosamine (GlcNAc) were synthesized, and the biological activities of the polymers were investigated. Glycosaminoglycans are the bioactive polysaccharides, which involves in the various living systems. Since the syntheses of glycosaminoglycans are difficult, the applicant investigated the new method to mimic the function of glycosaminoglycans by biopolymers. Site selective sulfonation of GlcNAc was performed and the acrylamide phenyl derivatives of sulfonated GlcNAc were synthesized. The polymers were synthesized with radical initiator. The biological activities with proteins were investigated. The polymers showed the affinities to the proteins of Alzheimer disease and cell growth factors. The porous materials with glycopolymers was also investigated. The siliceous porous materials were modified by poymer grafting and the protein separation was investigated.
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