Molecular pathways of fat-soluble ligands through the ubiquitin system

• Project/Area Number: 23687016
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Functional biochemistry
• Research Institution: National Institute of Health Sciences
• Principal Investigator: OHTAKE Fumiaki 国立医薬品食品衛生研究所, 毒性部, 主任研究官 (60447373)
• Project Period (FY): 2011-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000); Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2011: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
• Keywords: 転写因子 / 脂溶性リガンド / 蛋白質分解 / ユビキチン / 脂溶性化合物

Research Abstract

Fat-soluble small ligands possess diverse physiological roles in part through cellular receptor proteins. However, the underlying molecular mechanisms are not fully understood. In this study, we characterized a role of the ubiquitin system in regulating a fat-soluble ligand-dependent transcription factor.

Research Products

• [Journal Article] JMJD5, a JmjC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation (2012)
  • Author(s): Youn MY, 他(Ohtake F., 著者9人)
  • Journal Title: J Biol Chem Volume: 287 Pages: 12994-13004
  • Peer Reviewed
• [Journal Article] JMJD5, a jmjC-domain-containing protein, negatively regulates osteoclastogenesis through facillitating NFATc1 protein degradation (2012)
  • Author(s): Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehara KI, Yasuda H, Suzuki T, Kato S, Imai Y
  • Journal Title: J Biol Chem Volume: 287 Pages: 12994-3004
  • Peer Reviewed