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Molecular pathways of fat-soluble ligands through the ubiquitin system

Research Project

Project/Area Number 23687016
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionNational Institute of Health Sciences

Principal Investigator

OHTAKE Fumiaki  国立医薬品食品衛生研究所, 毒性部, 主任研究官 (60447373)

Project Period (FY) 2011-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2011: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords転写因子 / 脂溶性リガンド / 蛋白質分解 / ユビキチン / 脂溶性化合物
Research Abstract

Fat-soluble small ligands possess diverse physiological roles in part through cellular receptor proteins. However, the underlying molecular mechanisms are not fully understood. In this study, we characterized a role of the ubiquitin system in regulating a fat-soluble ligand-dependent transcription factor.

Report

(3 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (2 results)

All 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] JMJD5, a JmjC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation2012

    • Author(s)
      Youn MY, 他(Ohtake F., 著者9人)
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 12994-13004

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] JMJD5, a jmjC-domain-containing protein, negatively regulates osteoclastogenesis through facillitating NFATc1 protein degradation2012

    • Author(s)
      Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehara KI, Yasuda H, Suzuki T, Kato S, Imai Y
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 12994-3004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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