Molecular pathways of fat-soluble ligands through the ubiquitin system

Research Project

Project/Area Number	23687016
Research Category	Grant-in-Aid for Young Scientists (A)
Allocation Type	Single-year Grants
Research Field	Functional biochemistry
Research Institution	National Institute of Health Sciences
Principal Investigator	OHTAKE Fumiaki 国立医薬品食品衛生研究所, 毒性部, 主任研究官 (60447373)
Project Period (FY)	2011-04-01 – 2013-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000) Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000) Fiscal Year 2011: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords	転写因子 / 脂溶性リガンド / 蛋白質分解 / ユビキチン / 脂溶性化合物
Research Abstract	Fat-soluble small ligands possess diverse physiological roles in part through cellular receptor proteins. However, the underlying molecular mechanisms are not fully understood. In this study, we characterized a role of the ubiquitin system in regulating a fat-soluble ligand-dependent transcription factor.