Analysis of the spatiotemporal regulation of EGFR signal by LRRK1
| Project/Area Number |
23687030
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
HIROSHI Hanafusa 名古屋大学, 理学(系)研究科(研究院), 講師 (00345844)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | シグナル伝達 / メンブレントラフィック / LRRK1 / EGFR / CLIP-170 / CLIP170 / Dynactin / endosome |
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| Research Abstract |
Excess signal from EGFR leads to tumorigenesis. We reveal that LRRK1 regulates EGFR signal spatiotemporally through the regulation of intracellular trafficking of EGFR. Our findings indicate that (1) LRRK1 regulates EGFR transport from early to late endosomes, and (2) LRRK1 regulates efficient sorting of EGFR to the inner vesicles of endosome by interacting with STAM1, a component of ESCRT-0 complex. Furthermore, LRRK1 plays an important role in the initiation of EGFR trafficking by phosphorylating CLIP-170.
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Report
(4 results)
Research Products
(18 results)
