Genetic adaptation to agriculture in Asians: Insights from lifestyle-related diseases
Project/Area Number |
23687036
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Physical anthropology
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Research Institution | Jichi Medical University |
Principal Investigator |
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Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
|
Keywords | ゲノム多様性 / 生活習慣病 / SNP / モンゴル人 / 適応 / ゲノム人類学 / 遊牧生活 / 遺伝的多型 / 農耕 / 遊牧 / 進化 / メタボリック症候群 / 環境適応 / 遺伝子 / 遺伝的多様性 / 自然選択 / 牧畜 / 内臓脂肪 / 東アジア |
Research Abstract |
Mongolians, a nomadic group in East Asia, are different from agricultural East Asians in susceptibility to lifestyle-related diseases. Genetic adaptation to the distinctive occupations would partly contribute to the ethnic differences in the disease susceptibility. The present anthropological, genetic-epidemiological study revealed that Mongolians and agricultural East Asians (Japanese and Han Chinese) showed large genetic differentiations in gene sets related to metabolic disorders, including alcohol metabolism, fatty acid metabolism, gluconeogenesis/glycolysis, and adipogenesis. Additionally, novel gene influencing visceral fat accumulation in East Asians (TRIB2) was identified.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.2014
Author(s)
Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S; Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan
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Journal Title
J Mol Endocrinol
Volume: 52
Issue: 2
Pages: 145-158
DOI
Related Report
Peer Reviewed
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