| Project/Area Number |
23688033
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | GLP-1 / インスリン / 反芻動物 / 骨格筋 / 肝臓 / メタボロミクス / 代謝性ホルモン / 乳牛 / グレリン / 感受性マーカー |
|---|
| Outline of Final Research Achievements |
This study was conducted to explore the role of glucagon-like peptide-1 (7-36) amide (GLP-1) in partitioning nutrient metabolism in ruminant, and to investigate whether or not this role is independent of its effects on insulin secretion. GLP-1 infusion increased NEFA, β-hydroxybutyrate and TG, but decreased glucagon, T-Cho, NEAA, BCAA and UN plasma concentrations. And the results of metabolome analysis in liver and skeletal muscle revealed that GLP-1 infusion enhanced the gluconeogenic, lipolytic and ketogenic pathways and these pathways may be associated with decreased lipid clearance from the liver and skeletal muscle. In conclusion, GLP-1 exerts extrapancreatic roles in ruminants not only insulin-independent but probably, in contrast to non-ruminants, antagonistic to insulin effects.
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