CE-TOFMS-based metabolomics reveals effects of metabolic hormone in ruminant
| Project/Area Number |
23688033
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | GLP-1 / インスリン / 反芻動物 / 骨格筋 / 肝臓 / メタボロミクス / 代謝性ホルモン / 乳牛 / グレリン / 感受性マーカー |
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| Outline of Final Research Achievements |
This study was conducted to explore the role of glucagon-like peptide-1 (7-36) amide (GLP-1) in partitioning nutrient metabolism in ruminant, and to investigate whether or not this role is independent of its effects on insulin secretion. GLP-1 infusion increased NEFA, β-hydroxybutyrate and TG, but decreased glucagon, T-Cho, NEAA, BCAA and UN plasma concentrations. And the results of metabolome analysis in liver and skeletal muscle revealed that GLP-1 infusion enhanced the gluconeogenic, lipolytic and ketogenic pathways and these pathways may be associated with decreased lipid clearance from the liver and skeletal muscle. In conclusion, GLP-1 exerts extrapancreatic roles in ruminants not only insulin-independent but probably, in contrast to non-ruminants, antagonistic to insulin effects.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Ingestion of medium chain fatty acids by lactating dairy cows increases concentrations of plasma ghrelin2013
Author(s)
Fukumori R, Sugino T, Shingu H, Moriya N, Kobayashi H, Hasegawa Y, Kojima M, Kangawa K, Obitsu T, Kushibiki S, Taniguchi K
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Journal Title
Domest Anim Endocrinol
Volume: 45
Issue: 4
Pages: 216-223
DOI
Related Report
Peer Reviewed
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