| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Research Abstract |
Although allergic diseases have increased dramatically in recent years, effective therapy has yet to be established. The purpose of this study was to elucidate the mechanisms regulating allergic inflammation based on circadian rhythms in order to alleviate clinical signs/symptoms of allergy constantly in line with the circadian rhythms of the body. By using a mouse model for human atopic dermatitis and dogs, time-of-day dependent variations of allergic inflammation were detected, and were shown to be controlled by glucocorticoid derived from the adrenal glands. These results suggested that administration of glucocorticoid drugs based on circadian rhythms might efficiently regulate allergic reactions.
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