| Budget Amount *help |
¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2013: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
We have succeeded in the development of novel asymmetric catalysis without using rare earth metals. The newly developed chiral catalysts were , then, applied for the synthesis of compounds bearing chiral tetra-substituted stereocenters. Instead of previously used rare earth metals, abundant magnesium and manganese chiral catalysts were developed. High catalytic activity was achieved by fine design of multinuclear metal catalysts, and the multinulcear catalysts enabled easy access to chiral nitrogen-containing building blocks. With the new catalytic asymmetric reactions, we applied the reactions to the design and library synthesis of promising anti-tumor agents.
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