Development of tumor associated macrophages-selective DDS and its application to tumor therapy
| Project/Area Number |
23689003
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Nagasaki University (2013)
Kyoto University (2011-2012) |
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Principal Investigator |
KAWAKAMI Shigeru 長崎大学, 医歯(薬)学総合研究科, 教授 (20322307)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Keywords | ＤＤＳ / ターゲティング / リポソーム / 超音波 / 腫瘍関連マクロファージ / マンノース修飾リポソーム / ドラッグデリバリーシステム / がん治療 / 糖修飾リポソーム / バブルリポソーム / 核酸医薬品 / 癌治療 / マクロファージ |
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| Research Abstract |
Tumor-associated macrophages (TAM) exhibit an M2 phenotype that promotes tumor progression, and conversion of M2 TAM toward a tumouricidal M1 phenotype is a promising anti-cancer therapy. However, little has been reported on TAM-selective drug delivery because a specific ligand is lacked. Mannosylated carriers would be an effective approach, but they can be distributed to all of macrophages that highly expressed mannose receptors in the body. In this study, we succeeded to develop a mannosylated bubble lipoplex and ultrasound irradiation to tumor site for TAM-selective delivery of nucleic acid.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice2014
Author(s)
T. Kurosaki, S. Kawakami, Y. Higuchi, R. Suzuki, K. Maruyama, H. Sasaki, F. Yamashita, M. Hashida
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Journal Title
Nanomedicine, Nanotechnology, Biology, and Medicine
Volume: (in press)
Related Report
Peer Reviewed
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