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The regulation of bone metabolism by amino acid

Research Project

Project/Area Number 23689004
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKanazawa University

Principal Investigator

HINOI Eiichi  金沢大学, 薬学系, 准教授 (70360865)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords骨代謝 / 骨芽細胞 / 破骨細胞 / 遺伝子欠損マウス / アミノ酸 / 骨粗鬆症
Research Abstract

Although amino acid transporters are indispensable for a variety of cellular events in eukaryotic cells, little attention has been paid to their functional role in bone modeling and remodeling so far. Here, we have attempted to demonstrate the possible involvement of a system A amino acid transporter Slc38a1 in the regulation of osteoblastogenesis and osteoclastogenesis in vivo. To that end, cell-specific (osteoblast and osteoclast) knockout mice were generated. In vertebrae of those knockout mice, no marked change was seen in bone volume over tissue volume, osteoblastic parameter and osteoclastic parameter compared with wild-type (WT) mice by bone histomorphometric analyses. Moreover, ovariectomy resulted in a marked reduction of vertebrae bone volume in both WT mice and osteoblast-specific Slc38a1 knockout mice.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (17 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results) (of which Invited: 2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] An analysis of skeletal development in osteoblast- and chondrocyte-specific Runx2 knockout mice2013

    • Author(s)
      Takeshi Takarada, Eiichi Hinoi, Ryota Nakazato, Hiroki Ochi, Cheng Xu, Azusa Tsuchikane, Shu Takeda, Gerard Karsenty, Takaya Abe, Hiroshi Kiyonari, and Yukio Yoneda
    • Journal Title

      J. Bone Miner. Res

      Volume: 未定 Issue: 10 Pages: 2064-9

    • DOI

      10.1002/jbmr.1945

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells2013

    • Author(s)
      Le, N.Q., Binh, N.T., Takarada, T., Takarada-Iemata, M., Hinoi, E. and Yoneda, Y
    • Journal Title

      J. Pharmacol. Sci

      Volume: 122 Pages: 318-25

    • NAID

      10031196205

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23883486

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.2013

    • Author(s)
      Le NQ, Binh NT, Takarada T, Takarada-Iemata M, Hinoi E, Yoneda Y.
    • Journal Title

      J Pharmacol Sci.

      Volume: 122(4) Pages: 318-325

    • NAID

      10031196205

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin2012

    • Author(s)
      Hinoi, E., Nakatani, E., Yamamoto, T., Iezaki, T., Takahata, Y., Fujita, H., Ishiura, R., Takamori, M. and Yoneda, Y
    • Journal Title

      J. Bone Miner. Res

      Volume: 27 Issue: 12 Pages: 2526-34

    • DOI

      10.1002/jbmr.1708

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positive regulation of osteoclastic differentiation by growth differentiation factor-15 up-regulated in osteocytic cells under hypoxia2012

    • Author(s)
      Eiichi Hinoi, Hiroki Ochi, Takeshi Takarada, Eri Nakatani, Takashi Iezaki, Hiroko Nakajima, Hiroyuki Fujita, Yoshifumi Takahata, Shinya Hidano, Takashi Kobayashi, Shu Takeda, Yukio Yoneda
    • Journal Title

      J Bone Miner Res

      Volume: 4 Issue: 4 Pages: 938-949

    • DOI

      10.1002/jbmr.1538

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PossiblePossible involvement of glutamatergic signaling machineries in pathophysiology of rheumatoid arthritis2011

    • Author(s)
      Hinoi, E. and Yoneda, Y
    • Journal Title

      J. Pharmacol. Sci

      Volume: 116 Pages: 248-56

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/21666346

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of glutamatergic signaling machineries in pathophysiology of rheumatoid arthritis2011

    • Author(s)
      Hinoi, E.
    • Journal Title

      J Pharmacol Sci

      Volume: 116 Pages: 248-256

    • NAID

      10029894955

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Growth differentiation factor-15を介した骨細胞による破骨細胞活性化調節2014

    • Author(s)
      檜井栄一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市水道町鶴屋7Fカーネーションサロン(熊本県)
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素誘導性骨細胞由来因子GDF15による破骨細胞機能調節機構、第15回骨発生2012

    • Author(s)
      檜井栄一
    • Organizer
      再生研究会
    • Place of Presentation
      慶応大学(東京都)
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨格系細胞群のシグナル応答性解明研究2012

    • Author(s)
      檜井栄一
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2012-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨格系細胞群のシグナル応答性解明研究2012

    • Author(s)
      檜井栄一
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場(京都)(招待講演)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Growth differentiation factor-15を介した骨細胞 による破骨細胞活性化調節

    • Author(s)
      檜井栄一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市水道町鶴屋7Fカーネーションさろん(熊本県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 低酸素誘導性骨細胞由来因子GDF15による破骨細胞機能調節機構

    • Author(s)
      檜井栄一
    • Organizer
      第15回骨発生・再生研究会
    • Place of Presentation
      慶應大学(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~yakubutu/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~yakubutu/index.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 破骨細胞が関与する疾患の予防剤及び /又は治療剤2011

    • Inventor(s)
      米田幸雄、檜井栄一、山本朋未、家崎高志、石浦遼
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-238455
    • Filing Date
      2011-10-31
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 破骨細胞が関与する疾患の予防剤及び/又は治療剤2011

    • Inventor(s)
      檜井栄一, 他
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2011-238455
    • Filing Date
      2011-10-31
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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