| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Research Abstract |
The development of methods for differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cell (iPSCs) into functional cells have helped to analyze the mechanism in regulating cellular processes and to explore for cell-based assays for drug discovery. In this study, we developed methods for differentiation of ESCs and/or iPSCs into bone cells (osteoclast, osteoblast and osteocyte). In addition, we succeeded in identifying transcription factors involved in osteoblast and/or osteocyte differentiation. Our studies could provide important therapeutic targets for bone disease.
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