Controlling cellular function via modulating cytosolic chloride dynamics
| Project/Area Number |
23689011
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Fukui (2013)
Kyoto University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | Ｃｌダイナミクス / Ｃａダイナミクス / 細胞内小器官 / Clダイナミクス / Caダイナミクス |
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| Research Abstract |
The purpose of the present study was to clarify the mechanisms and significances of "cellular Cl-Ca dynamics coupling". To achieve the goals, I picked up two kinds of cells, cardiomyocytes and lymphocytes as typical excitable and non-excitable cells, respectively, and performed a combination study of cellular physiological experiments and mathematical simulations. As a result, I obtained following achievements. 1. There is an intracellular Cl store which is involved in the cellular Cl dynamics. 2. "Cellular Cl-Ca dynamics coupling" do exist. 3. Mitochondria are major organelle which participate in the "cellular Cl-Ca dynamics coupling".
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Impairment of Ubiquitin-Proteasome System by E334K cMyBPC Modifies Channel Proteins, Leading to Electrophysiological Dysfunction2011
Author(s)
Bahrudin U, Morikawa K, Takeuchi A, Kurata Y, Miake J, Mizuta E, Adachi K, Higaki K, Yamamoto Y, Shirayoshi Y, Yoshida A, Kato M, Yamamoto K, Nanba E, Morisaki H, Morisaki T, Matsuoka S, Ninomiya H, Hisatome I
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Journal Title
J Mol Biol
Volume: 413(4)
Issue: 4
Pages: 857-78
DOI
Related Report
Peer Reviewed
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