| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
The purpose of the present study was to clarify the mechanisms and significances of "cellular Cl-Ca dynamics coupling". To achieve the goals, I picked up two kinds of cells, cardiomyocytes and lymphocytes as typical excitable and non-excitable cells, respectively, and performed a combination study of cellular physiological experiments and mathematical simulations. As a result, I obtained following achievements. 1. There is an intracellular Cl store which is involved in the cellular Cl dynamics. 2. "Cellular Cl-Ca dynamics coupling" do exist. 3. Mitochondria are major organelle which participate in the "cellular Cl-Ca dynamics coupling".
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