Analysis of a novel D-Serine signaling underlying synaptic plasticity and motor learning
Project/Area Number |
23689012
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
General physiology
|
Research Institution | Keio University |
Principal Investigator |
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
|
Keywords | 神経科学 / 生理学 / 生体分子 / アミノ酸 / シナプス |
Research Abstract |
In this study, we examined the functional role of a D-serine highly existing in the developing cerebella. D-Serine in the cerebellum, which was released from glial cells in a neuronal activity-dependent manner, bound to the postsynaptically-expressing delta2-type ionotropic glutamate receptors (delta2 receptors) to regulate synaptic plasticity, a molecular basis of learning and memory. Interestingly, we revealed that delta2 receptor controlled the synaptic plasticity by binding to the tyrosine phosphatase PTPMEG via its intracellular C-terminus. Thus, D-serine-delta2 signaling is a unique D-serine signaling, which may gain new insights into the glia-neuron interaction.
|
Report
(4 results)
Research Products
(29 results)
-
-
-
-
-
[Journal Article] CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.2013
Author(s)
Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Tanaka M, Iwasato T, Itohara S, Furuyama K, Kawaguchi Y, Ishizaki Y, Yuzaki M, Furuichi T.
-
Journal Title
J Neurosci.
Volume: 33
Issue: 44
Pages: 17326-17334
DOI
Related Report
Peer Reviewed
-
[Journal Article] Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans.2013
Author(s)
Hills LB, Masri A, Konno K, Kakegawa W, Lam A-TN, Lim-Melia E, Chandy N, Hill RS, Panlow JN, Al-Saffar M, Nasir R, Stoler JM, Barkovich AJ, Watanabe M, Yuzaki M, Mochisa GH.
-
Journal Title
Neurology
Volume: 15;81(16)
Issue: 16
Pages: 1378-86
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-