| Budget Amount *help |
¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
Fiscal Year 2012: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2011: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
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| Research Abstract |
Cancer stem cells are thought to be responsible for both metastasis and cancer recurrence. We utilized FACS sorting to isolate cancer stem cells (CSCs) and non-cancer stem cells from xenograft human colon tumors to analyze gene expression. RNA-seq analysis revealed that 374 genes were significantly up-regulated in CSCs. Furthermore, we found that knockdown of any of 13 genes resulted in decreased growth ofCSCs. Hereafter, we will investigate the importance of these genes in CSC behavior.
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