Roles of the ubiquitin ligase, SCRAPPER, in intracellular transport
| Project/Area Number |
23689021
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Hamamatsu University School of Medicine (2013)
Kansai Medical University (2011-2012) |
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Principal Investigator |
YAO Ikuko 浜松医科大学, メディカルフォトニクス研究センター, 准教授 (60399681)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | シナプス / 蛋白質 / 神経可塑性 / ユビキチン / SCRAPPER / 質量分析 / イメージング / 老化 / 極性 |
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| Outline of Final Research Achievements |
Selective protein degradation is crucial in regulation of various cellular functions. The degradation machinery is supposed to play important roles in intracellular transport. To address this issue, we studied the regulation of the dynamics of motor protein by the ubiquitin ligase, especially focused on SCRAPPER, which we previously identified (Yao et al., Cell 2007)
We revealed reciprocal interactions between SCRAPPER and the motor protein and found that the amount of the motor protein was regulated by SCRAPPER dependent ubiquitination and the proteasomal degradation. With mass spectrometry imaging technique, we also identified some candidates of molecules that showed significant modulation in the brain sections of Scrapper gene knockout mice compared with those of wild type mice.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.2014
Author(s)
Yuki D, Sugiura Y, Zaima N, Akatsu H, Takei S, Yao I, Maesako M, Kinoshita A, Yamamoto T, Kon R, Sugiyama K, Setou M.
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Journal Title
Sci Rep
Volume: -
Issue: 1
Pages: 7130-7130
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 先駆ける研究に至るまで2014
Author(s)
矢尾育子
Organizer
第3回東北脳科学ウィンタースクール
Place of Presentation
東北大学（宮城県仙台市）
Year and Date
2014-02-15
Related Report
Invited
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