Searching for susceptibility genes in narcolepsy, and the therapeutic application
| Project/Area Number |
23689022
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Human genetics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
MIYAGAWA TAKU 東京大学, 医学(系)研究科(研究院), 助教 (20512263)
|
|---|
| Project Period (FY) |
2011-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
|
|---|
| Keywords | ゲノム / 遺伝学 / ゲノムワイド関連解析 / ナルコレプシー / 睡眠障害 / カルニチン / HLA / CNV / 脂肪酸代謝 / Copy number variation |
|---|
| Outline of Final Research Achievements |
I performed association studies to identify novel genetic factors for narcolepsy. HLA-DQB1*03:02, HLA-DPB1*05:01 and low frequency CNVs in PARK2 gene region were found to be associated with narcolepsy. In addition, I found a significant association between essential hypersomnia and a SNP in CRAT gene region.
To assess the efficacy of oral l-carnitine for the treatment of narcolepsy, I performed a clinical trial administering L-carnitine (510 mg/day) to patients with narcolepsy. L-carnitine treatment significantly improved the total time for dozing off during the daytime compared with that of placebo-treated periods. This study suggests that oral L-carnitine can be effective in reducing excessive daytime sleepiness in narcolepsy patients.
|
Report
(5 results)
Research Products
(37 results)
-
[Journal Article] New susceptibility variants to narcolepsy identified in HLA class II region2015
Author(s)
Miyagawa T, Toyoda H, Hirataka A, Kanbayashi T, Imanishi A,（省略）, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K.
-
Journal Title
Human Molecular Genetics
Volume: 24(3)
Pages: 891-898
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Immune-related pathways including HLA-DRB1*13:02 are associated with panic disorder2015
Author(s)
Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Kashiwase K, Sugaya N, Kawamura Y, Umekage T, Kojima H, Saji H, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Tokunaga K, Sasaki T.
-
Journal Title
Brain, Behavior, and Immunity
Volume: 掲載確定
Pages: 掲載確定
DOI
Related Report
Peer Reviewed
-
[Journal Article] High-accuracy imputation for HLA class I and II genes based on high-resolution SNP data of population-specific references2015
Author(s)
Khor SS, Yang W, Kawashima M, Kamitsuji S, Zheng X, Nishida N, Sawai H, Toyoda H, Miyagawa T, Honda M, Kamatani N, Tokunaga K.
-
Journal Title
The Pharmacogenomics Journal
Volume: 掲載確定
Pages: 掲載確定
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Genetic overlap between antipsychotic response and susceptibility to schizophrenia2015
Author(s)
Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N.
-
Journal Title
Journal of Clinical Psychopharmacology
Volume: 35(1)
Pages: 85-88
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
