The role of tandem repeat antigens in immune escape
| Project/Area Number |
23689024
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Parasitology (including Sanitary zoology)
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
YASUYUKI Goto 東京大学, 農学生命科学研究科, 准教授 (50553434)
|
|---|
| Project Period (FY) |
2011-11-18 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|
|---|
| Keywords | 抗原 / タンデムリピート / 寄生虫 / リーシュマニア症 / タンデムリピート抗原 / B細胞 / BAFF / 寄生虫症 / 液性免疫 / 免疫回避 |
|---|
| Research Abstract |
Tandem repeat (TR) proteins of protozoan parasites have been reported as strong B cell antigens, whereas the mechanisms for the antigenicity or the biological meaning of the antigenic TR proteins remain unknown. In this study, we revealed through genome analyses of Kinetoplastida parasites that the presence of huge TR genes is related to the pathogenesis to mammals. Besides, we found a distinct antibody production pattern to TR antigens compared to non-TR antigens, indicating the unique mechanism for TR antigens to be recognized by B cells. Furthermore, we identified BAFF as a candidate molecule related to excessive activation of humoral responses during leishmaniasis. Taken together, these findings will be a great step towards understanding immune escape mechanisms of protozoan parasites by using TR antigens.
|
Report
(4 results)
Research Products
(56 results)
-
-
-
[Journal Article] Localization and expression profiling of a 31 kDa antigenic repetitive protein Sjp_0110390 in Schistosoma japonicum life stages2013
Author(s)
Angeles JM, Kirinoki M, Goto Y, Asada M, Hakimi H, Leonardo LR, Tongol-Rivera P, Villacorte EA, Inoue N, Chigusa Y, Kawazu SI
-
Journal Title
Mol Biochem Parasitol
Volume: 187
Issue: 2
Pages: 98-102
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Localization and expression profiling of a 31 kDa antigenic repetitive protein Sjp_0110390 in Schistosoma japonicum life stages2013
Author(s)
Angeles J, Kirinoki M, Goto Y, Asada M, Hakimi H, Leonardo L, Rivera P, Villacorte E, Inoue N, Chigusa Y, Kawazu S
Organizer
第82回日本寄生虫学会大会
Place of Presentation
東京医科歯科大学、東京
Year and Date
2013-03-30
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] Localization and expression profiling of a 31 kDa antigenic repetitive protein Sjp_0110390 in Schistosoma japonicum life stages2013
Author(s)
Jose Ma. M. Angeles, Masashi Kirinoki, Yasuyuki Goto, Masahito Asada, Hassan Hakimi, Lydia R. Leonardo, Pilarita Rivera, Elena A. Villacorte, Noboru Inoue, Yuichi Chigusa, Shin-ichiro Kawazu
Organizer
第82回日本寄生虫学会大会
Place of Presentation
東京医科歯科大学
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
