Basic characteristics of urinary insecticide and its metabolite levels in Japanese
Project/Area Number |
23689034
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Hygiene
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Research Institution | Nagoya University |
Principal Investigator |
UEYAMA Jun 名古屋大学, 医学(系)研究科(研究院), 准教授 (00397465)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
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Keywords | 農薬曝露 / バイオモニタリング / 曝露評価 / 分析化学 / 尿中殺虫剤代謝物 / 殺虫剤 / 高感度分析 / 小児 / 曝露量 |
Research Abstract |
In Japan, the consumption of pesticides was estimated to be 1.2 ton/km2 of arable and permanent cropland in 2007, which was much higher than those of other OECD countries. The aim of this study is to clarify the characteristics of urinary insecticide and its metabolite levels in Japanese. We developed a simple, precise, and high-throughput method for the detection of urinary pyrethroid metabolites CDCA and 3-PBA extracted from disposable diapers. Moreover, a rapid and sensitive analytical method using GC-MS and LC-MS/MS was developed for the measurement of 7 neonicotinoids (NEO) and its metabolites from human urine. These methods can be applied to routine biological monitoring of urinary biomarkers associated with insecticide exposure not only in adults but young children. These methods were validated by cross validation assay and external quality control assay (G-EQUAS 51). We suggested that the levels of some biomarkers were depends on sampling season, age and pesticide usage.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers2012
Author(s)
Ueyama J, Saito I, Kondo T, Taki T, Kimata A, Saito S, Ito Y, Murata K, Iwata T, Gotoh M, Shibata E, Wakusawa S, Kamijima M
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Journal Title
Chemosphere
Volume: 87(11)
Pages: 1403-9
Related Report
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[Journal Article] Prevalence of Helicobacter pylori infection measured with urinary antibody in an urban area of Japan, 2008-20102012
Author(s)
Tamura T, Morita E, Kondo T, Ueyama J, Tanaka T, Kida Y, Hori Y, Inoue S, Tomita K, Okada R, Kawai S, Hishida A, Naito M, Wakai K, Hamajima N
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Journal Title
Nagoya J Med Sci
Volume: 74(1-2)
Pages: 63-70
NAID
Related Report
Peer Reviewed
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[Journal Article] Study profile on baseline survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)2011
Author(s)
Morita E, Hamajima N, Hishida A, Aoyama K, Okada R, Kawai S, Tomita K, Kuriki S, Tamura T, Naito M, Kondo T, Ueyama J, Kimata A, Yamamoto K, Hori Y, Hoshinos J, Hamamotos R, Tsukamoto S, Onishi J, Hagikura S, Naito H, Hibi S, Ito Y, Wakai K
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Journal Title
Nagoya J Med Sci
Volume: 73(3-4)
Pages: 187-95
NAID
Related Report
Peer Reviewed
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[Journal Article] Study Profile on Baseline Survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)2011
Author(s)
MORITA Emi, HAMAJIMA Nobuyuki, HISHIDA Asahi, AOYAMA Kyoko, OKADA Rieko, KAWAI Sayo, TOMITA Koutaro, KURIKI Sayaka, TAMUBA Takashi, NAITO Mariko, KONDO Takaaki, UEYAMA Jun, KIMATA Akiko, YAMAMOTO Kanami, HORI Yoko, HOSHINO Junko, HAMAMOTO Ritsuko, TSUKAMOTO Sanae, ONISHI Johji, HAGIKURA Shoichi, NAITO Hisao, HIBI Satoshi, ITO Yoshinori, WAKAI Kenji
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Journal Title
Nagoya Journal of Medical Science
Volume: 73
Pages: 187-187
NAID
Related Report
Peer Reviewed
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[Journal Article] Association of UGT1A1 Gly71Arg with urine urobilinogen2011
Author(s)
KATAOKA Ryuji, KIMATA Akiko, YAMAMOTO Kanami, HIROSAWA Naoko, UEYAMA Jun, KONDO Takaaki, OKADA Rieko, KAWAI Sayo, HISHIDA Asahi, NAITO Mariko, MORITA Emi, WAKITA Kenji, HAMAJIMA Nobuyuki
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Journal Title
Nagoya Journal of Medical Science
Volume: 73
Pages: 33-33
NAID
Related Report
Peer Reviewed
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[Presentation] Concentration of urinary organophosphorus insecticide metabolites in Japanese workers2011
Author(s)
UEYAMA Jun, Saito Isao, KONDO Takaaki, TAKI Tomoko, KIMATA Akiko, SAITO Shun, MURATA Katsuyuki, IWATA Toyoto, GOTO Masahiro, SHIBATA Eiji, WAKUSAWA Shinya, KAMIJIMA Michihiro
Organizer
21 th Annual meeting of the international society of exposure science
Place of Presentation
アメリカ ボルチモア
Year and Date
2011-10-24
Related Report
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[Presentation] Concentration of urinary organophosphorus insecticide metabolites in Japanese workers2011
Author(s)
UEYAMA Jun, Saito Isao, KONDO Takaaki, TAKI Tomoko, KIMATA Akiko, SAITO Shun, MURATA Katsuyuki, IWATA Toyoto, GOTO Masahiro, SHIBATA Eiji, WAKUSAWA Shinya, KAMIJIMA Michihiro
Organizer
21th Annual meeting of the international society of exposure science
Place of Presentation
ボルチモア、アメリカ
Related Report
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