| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Many epidemiological and animal model studies suggest the cancer chemopreventive effects of food. However, little is known about the direct molecular targets of food factors. In this study, we succeeded in comprehensively identifying the binding proteins of four representative food factors using our original Chemical Biology method. Moreover, we discovered novel cancer-promoting functions of these binding proteins and revealed the detailed mechanisms underlying growth inhibition by food factors. In the future, identification of food factor-binding proteins might realize the tailor-made prevention of cancer based on expression levels and SNPs of these binding proteins.
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