Comprehensive identification of cancer chemopreventive target molecules by Chemical Biology and the tailor-made prevention of cancer
| Project/Area Number |
23689036
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IIZUMI Yosuke 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20533178)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | がん予防 / 結合タンパク質 / 食品成分 / ナノ磁性ビーズ / 細胞周期 / 細胞死 / 質量分析 / 新規メカニズム / ケミカルバイオロジー / 結合蛋白 / 質量分析計 / NF-kappaB |
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| Outline of Final Research Achievements |
Many epidemiological and animal model studies suggest the cancer chemopreventive effects of food. However, little is known about the direct molecular targets of food factors. In this study, we succeeded in comprehensively identifying the binding proteins of four representative food factors using our original Chemical Biology method. Moreover, we discovered novel cancer-promoting functions of these binding proteins and revealed the detailed mechanisms underlying growth inhibition by food factors. In the future, identification of food factor-binding proteins might realize the tailor-made prevention of cancer based on expression levels and SNPs of these binding proteins.
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Vesnarinone Suppresses TNF α mRNA Expression by Inhibiting Valosin-containing Protein2013
Author(s)
Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Ando H, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H, Handa H
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Journal Title
Mol Pharmacol
Volume: Vol.83
Issue: 5
Pages: 930-938
DOI
Related Report
Peer Reviewed
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