| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
|---|
| Research Abstract |
Aging is associated with various diseases, including diabetes mellitus and heart failure. However, the molecular mechanism of aging is not known yet. In the present study, we identified that complement C1q, which plays an important role in immune system, increases with advancing age and plays a pivotal role in aging and in the pathophysiology of various 'aging-associated disorders'. Complement C1q impairs skeletal muscle regeneration through activation of Wnt signaling and inhibition of C1q-induced Wnt signaling activation recovered the regenerative capacity of the aged mice. Elevation of C1q is also observed in obesity- and aging-induced diabetes, and may play causative role in pathogenesis of diabetes. We also identified that C1q expression is increased during heart failure and that cardiomyocyte-specific and endothelial cell-specific Wnt signaling activation leads to progressive cardiac dysfunction and heart failure.
|
