Development of diagnostic technologies for ALK-positive lung cancer
| Project/Area Number |
23689043
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jichi Medical University |
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Principal Investigator |
SODA Manabu 自治医科大学, 医学部, ポストドクター (10406118)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | EML4-ALK / 肺がん / multiplex RT-PCR法 / RT-PCR |
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| Research Abstract |
EML4-ALK and KIF5B-ALK lung cancer oncogenes have various fusion variants. We thus developed a multiplex RT-PCR system to capture all possible in-frame fusions for these oncogenes, and conducted a large-scale, prospective screening for Japanese cohort of
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] Transforming mutations of RAC guanosine triphosphatases in human cancers2013
Author(s)
Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T, Yamashita Y, Katada T, Choi YL, & Mano H
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Journal Title
PNAS.
Volume: 110
Pages: 3029-334
Related Report
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[Journal Article]2013
Author(s)
Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T,Yamashita Y, Katada T, Choi YL, Mano H,
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110
Issue: 8
Pages: 3029-3034
DOI
Related Report
Peer Reviewed
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[Journal Article] ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity2012
Author(s)
Kimura H, Nakajima T, Takeuchi K, Soda M, Mano H, Iizasa T, Matsui Y, Yoshino M, Shingyoji M, Itakura M, Itami M, Ikebe D, Yokoi S, Kageyama H, Ohira M & Nakagawara A
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Journal Title
Lung Cancer
Volume: 75
Pages: 66-72
Related Report
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[Journal Article] A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer2012
Author(s)
Ng KP, Hillmer AM, Chuah CT, Juan WC, Ko TK, Teo AS, Ariyaratne PN, Takahashi N, Sawada K, Fei Y, Soh S, Lee WH, Huang JW, Allen JC, Jr., Woo XY, Nagarajan N, Kumar V, Thalamuthu A, Poh WT, Ang AL, Mya HT, How GF, Yang LY, Koh LP, Chowbay B, Chang CT, Nad
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Journal Title
Nat Med
Volume: 18
Pages: 521-528
Related Report
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[Journal Article] A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancer2012
Author(s)
Soda M, Isobe K, Inoue A, Maemondo M, Oizumi S, Fujita Y, Gemma A, Yamashita Y, Ueno T, Takeuchi K, Choi YL, Miyazawa H, Tanaka T, Hagiwara K & Mano H
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Journal Title
Clin Cancer Res
Volume: 18
Pages: 5682-5689
Related Report
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[Journal Article] RET, ROS1 and ALK fusions in lung cancer2012
Author(s)
Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H, Choi YL, Satoh Y, Okumura S, Nakagawa K, Mano H & Ishikawa Y
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Journal Title
Nat Med
Volume: 18
Pages: 378-381
Related Report
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[Journal Article] Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells2012
Author(s)
Yamada T, Takeuchi S, Nakade J, Kita K, Nakagawa T, Nanjo S, Nakamura T, Matsumoto K, Soda M, Mano H, Uenaka T & Yano S
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Journal Title
Clin Cancer Res
Volume: 18
Pages: 3592-3602
Related Report
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[Journal Article]2012
Author(s)
Soda M, Isobe K, Inoue A, Maemondo M,Oizumi S, Fujita Y, Gemma A, Yamashita Y,Ueno T, Takeuchi K, Choi YL, Miyazawa H,Tanaka T, Hagiwara K, Mano H
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Journal Title
Clin Cancer Res
Volume: 18
Issue: 20
Pages: 5682-5689
DOI
Related Report
Peer Reviewed
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[Journal Article] Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK-fusion identification"2011
Author(s)
Takeuchi K, Soda M, Togashi Y, Sugawara E, Hatano S, Asaka R, Okumura S, Nakagawa K, Mano H, Ishikawa Y
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Journal Title
Clin Cancer Res
Volume: 17
Pages: 3341-3348
Related Report
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