| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2012: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2011: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Research Abstract |
Decrease of SCAP, a sterol sensor molecule, was observed in the brain of STZ-induced severe diabetes mouse model. Homozygous disruption of the Scap gene in the brains of mice caused perinatal lethality associated with microcephaly. Mice with haploinsufficiency of Scap in the brain showed reduction in brain cholesterol synthesis, similar to what was observed in diabetic mice. This resulted in impaired synaptic transmission, as measured by decreased long-term potentiation, and was associated with behavioral and cognitive changes. Thus, reduction of SCAP and the consequent suppression of cholesterol synthesis in the brain may play an important role in the increased rates of cognitive decline observed in diabetic states.
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