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Genetic prediction of Th1 and Th17 cells activity in rheumatoid arthritis

Research Project

Project/Area Number 23689051
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KOCHI Yuta  独立行政法人理化学研究所, 自己免疫疾患研究チーム, 上級研究員 (60415156)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords関節リウマチ / 遺伝学 / Th1 細胞 / Th17 細胞 / 遺伝子多型 / Th1細胞 / Th17細胞 / 病態予測
Research Abstract

This study aimed to establish a model to predict sub-phenotypes in rheumatoid arthritis (RA) by using genetic polymorphisms, with a special focus on Th1- and Th17-cell activity. We quantified IFN-γ and IL-17A levels in the sera of RA patients (n=836). In addition, we genotyped polymorphisms in HLA-DRB1 and Th1/Th17 related genes. By using the genotypes and clinical information, we successfully predicted the status of IFN-γ and IL-17A with a logistic regression model (AUC in the ROC curve =0.887).

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (1 results) Book (1 results) Remarks (3 results)

  • [Journal Article] 自己免疫疾患のゲノム解析2013

    • Author(s)
      高地雄太
    • Journal Title

      Pharma Medica

      Volume: 31(1) Pages: 9-12

    • Related Report
      2012 Final Research Report
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y,et al
    • Journal Title

      Nat Genet

      Volume: 44(5) Pages: 511-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-kappaB Pathway Are Associated with Rheumatoid Arthritis in Japanese2012

    • Author(s)
      Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A, Ikari K, Tsunoda T, Takahashi, et al
    • Journal Title

      PLoS Genet

      Volume: 8(9)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ゲノムと免疫疾患2012

    • Author(s)
      高地雄太
    • Journal Title

      最新医学

      Volume: 68(3) Pages: 638-647

    • Related Report
      2012 Final Research Report
  • [Journal Article] Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q122012

    • Author(s)
      Kurreeman FA
    • Journal Title

      American Journal of Human Genetics

      Volume: 90 Issue: 3 Pages: 524-532

    • DOI

      10.1016/j.ajhg.2012.01.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.2012

    • Author(s)
      Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A et al.
    • Journal Title

      PLoS Genet

      Volume: 8 Issue: 9 Pages: e1002949-e1002949

    • DOI

      10.1371/journal.pgen.1002949

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Kochi Y, et al
    • Journal Title

      Nature Genetics

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455

    • DOI

      10.1371/journal.pgen.1002455

    • NAID

      120005906866

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膠原病の疾患感受性遺伝子2011

    • Author(s)
      高地雄太
    • Journal Title

      内科

      Volume: 107(4) Pages: 641-644

    • Related Report
      2012 Final Research Report
  • [Journal Article] CCR6 遺伝子と関節リウマチ2011

    • Author(s)
      高地雄太
    • Journal Title

      リウマチ科

      Volume: 45(5) Pages: 526-530

    • Related Report
      2012 Final Research Report
  • [Journal Article] 疾患感受性遺伝子とは2011

    • Author(s)
      高地雄太
    • Journal Title

      臨床検査

      Volume: 55(11) Pages: 1074-1080

    • Related Report
      2012 Final Research Report
  • [Presentation] 関節リウマチチにおけるゲノムワイド関連解析2011

    • Author(s)
      高地雄太
    • Organizer
      阿蘇シンポジウム
    • Place of Presentation
      阿蘇市
    • Year and Date
      2011-07-29
    • Related Report
      2012 Final Research Report
  • [Book] 免疫学Update2012

    • Author(s)
      審良静男
    • Publisher
      南山堂
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.src.riken.jp/group/auto/index.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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