Production and application of generator system of short-lived alpha emitter 211At for radionuclide therapy in a remote location
| Project/Area Number |
23689056
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | α放射体 / 放射線 / 癌 / 薬学 / 内用療法 / アスタチン-211 / ジェネレータ / アスタチン－２１１ |
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| Research Abstract |
Although an alpha emitter astatine-211 is the most promising raddionuclide for treatment of cancer, its short half-life limited the use of it only at nearby hospitals. Here we produced 211Rn/211At generator using solvent extraction method, which enables to deliver 211At more distant site from product facilities.
211Rn was prodcued by 209Bi(7Li, 5n)211Rn reaction at the JAEA-Tokai tandem accelerator. The irradiated target was dissolved in dilute nitric acid and 211Rn was extracted by solvent extraction using dodecane as a organic solvent. The dodecane was stand for 12 hours to generate 211At, then 211At was back extracted using methanol. It was found that exraction rate of 211Rn into dodecane was 82% while target material and other by-product radionuclides were hardly extracted. The recovery yield of 211At form dodecane to methanol was 98%.
These results showed that 211Rn/211At generator using solvent extraction system is easy to handle and will be feasible product.
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Report
(4 results)
Research Products
(31 results)
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[Presentation] Production and separation of radioactive astatine isotopes in the 7Li+natPb reaction2013
Author(s)
I. Nishinaka, A. Yokoyama, K. Washiyama, R. Amano, E. Maeda, N. Yamada, H. Makii, A. Toyoshima, S. Watanabe, N. S. Ishioka, K. Hashimoto
Organizer
8thInternatinal Symposium on Targeted Alpha Therapy
Place of Presentation
Oak Ridge, TN (USA)
Related Report
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[Presentation] Preclinical evaluation of [211At]-astatinated humanized MX35 for targeted alpha therapy: Comparison with murine MX35 in an s.c. ovarian tumor model2013
Author(s)
Sture Lindegren, Kohshin Washiyama, Emma Aneheim, Elin Cederkrantz, Holger Jensen,Per Albertsson, Ragnar Hultborn, Stig Palm, Tom Back, Fernando Perez
Organizer
8thInternatinal Symposium on Targeted Alpha Therapy
Place of Presentation
Oak Ridge, TN (USA)
Related Report
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[Presentation] Production and Utilization of Radioactive Astatine Isotopes in the 7Li+natPb Reaction2013
Author(s)
I. Nishinaka, A. Yokoyama, K. Washiyama, R. Amano, E. Maeda, N. Yamada, H. Makii, A. Toyoshima, S. Watanabe, N. S. Ishioka, K. Hashimoto
Organizer
5th Asia-Pacific Symposium on Radiochemistry
Place of Presentation
Kanazawa Bunka Hal （石川県）
Related Report
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[Presentation] Nuclear and Radiochemical Study of Production and utilization of radioactive astatine isotopes in the 7Li+natPb reaction2012
Author(s)
NISHINAKA, Ichiro; YOKOYAMA, Akihiko; WASHIYAMA, Kohshin; AMANO, Ryohei; MAEDA, Eita; YAMADA, Norihiro; MAKII, Hiroyuki; WATANABE, Shigeki; ISHIOKA, Noriko; HASHIMOTO, Kazuyuki
Organizer
8th International Conferences on Nuclear and Radiochemistry
Place of Presentation
Grand Hotel di Como (Italy)
Related Report
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