Development of 4-dimensional in-vivo dosimetry for proton beam therapy and application to a precise 4-dimensional proton beam treatment

• Project/Area Number: 23689058
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: KOHNO Ryosuke 独立行政法人国立がん研究センター, その他部局等, 研究員 (20392227)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 陽子線治療 / 体内線量測定 / モンテカルロ法 / GPGPU / ４次元CT / MOSFET検出器 / ４次元位置検出器 / in-vivo dosimetry / RADPOS / ４次元体内線量測定

Outline of Final Research Achievements

We achieved a high accuracy and high speed of dose calculation for proton beam therapy. In order to evaluate body motion, performance of 4-dimensional CT was evaluated, and we examined operation method of the 4-dimensional CT. With the aim of high-precision in-vivo proton dosimetry, in-vivo dosimetry was performed by using a 4-dimensional position sensor and a MOSFET detector. We could successfully control the uncertainty of the measurement position by using the 4-dimensional position sensor within 1 mm for in-vivo proton dosimetry.

Research Products

• [Journal Article] Evaluating positional accuracy using megavoltage cone-beam computed tomography for IMRT with head-and-neck cancer (2014)
  • Author(s): Motegi K, Kohno R, Ueda T, Shibuya T, Ariji T, Kawashima M, Akimoto T
  • Journal Title: J Radiat Res Volume: 55 Issue: 3 Pages: 568-574
  • DOI: 10.1093/jrr/rrt143
  • Peer Reviewed
• [Journal Article] Application of the pencil-beam redefinition algorithm in heterogeneous media for proton therapy (2013)
  • Author(s): Y. Egashira, T. Nishio, K. Hotta, R. Kohno, M. Uesaka
  • Journal Title: Phys. Med. Biol. Volume: 58(4) Issue: 4 Pages: 1169-1184
  • DOI: 10.1088/0031-9155/58/4/1169
  • Peer Reviewed
• [Journal Article] Experimental verification of dose calculation using the simplified Monte Carlo method with an improved initial beam model for a beam-wobbling system (2013)
  • Author(s): Ryohei Tansho1, Yoshihisa Takada1, Ryosuke Kohno, Kenji Hotta, Yousuke Hara, Shohei Mizutani and Tetsuo Akimoto
  • Journal Title: Phys. Med. Biol. Volume: 58 Issue: 17 Pages: 6047-6064
  • DOI: 10.1088/0031-9155/58/17/6047
  • Peer Reviewed
• [Journal Article] Locoregional control after intensity-modulated radiotherapy for nasopharyngeal carcinoma with an anatomy-based target definition (2013)
  • Author(s): M. Kawashima, T. Ariji, S. Kameoka, T. Ueda, R. Kohno, T. Nishio, S. Arahira, A. Motegi, S. Zenda, T. Akimoto, R. Hayashi
  • Journal Title: Jpn. J. Clin. Oncol. Volume: 43(12) Issue: 12 Pages: 1218-1225
  • DOI: 10.1093/jjco/hyt144
  • Peer Reviewed
• [Journal Article] 陽子線がん治療における体内「線量分布」を考える-粒子線治療における医学物理の必要性- (2013)
  • Author(s): 河野良介,堀田健二、秋元哲夫
  • Journal Title: 癌の臨床 Volume: 59 Pages: 169-176
• [Journal Article] Experimental evaluation of actual delivered dose using mega-voltage cone-beam CT and direct point dose measurement (2012)
  • Author(s): Kana Matsubara, M.S.; Ryosuke Kohno, Ph.D.; Shie Nishioka, Ph.D.; Toshiyuki Shibuya, B.Sc.; Takaki Ariji, B.Sc.; Tetsuo Akimoto, M.D. Ph.D.; Hidetoshi Saitoh, Ph.D
  • Journal Title: Med. Dosim. Volume: 38 Issue: 2 Pages: 153-159
  • DOI: 10.1016/j.meddos.2012.10.005
  • Peer Reviewed
• [Journal Article] In vivo proton dosimetry using a MOSFET detector in an anthropomorphic phantom with tissue inhomogeneity (2012)
  • Author(s): R Kohno
  • Journal Title: J. Appl. Clin. Med. Phys. Volume: 13 Issue: 2 Pages: 159-167
  • DOI: 10.1120/jacmp.v13i2.3699
  • Peer Reviewed
• [Journal Article] Proton Beam Therapy for Unresectable Malignancies of The Nasal Cavity and Paranasal Sinuses (2011)
  • Author(s): Sadmoto Zenda ,Takashi Ogino, et al.
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 81(5) Issue: 5 Pages: 1473-1478
  • DOI: 10.1016/j.ijrobp.2010.08.009
  • Peer Reviewed
• [Journal Article] Dose-volume histgram analysis of the safety of proton beam therapy for unresectable hepatocellular carcinoma (2011)
  • Author(s): M.Kawashima, R.Kohno, K.Nakachi, T.Nishio, S.Mitusnaga, M.Ikeda, M.Konishi, S.Takahasi, N.Gotohda, S.Arahira, S.Zenda, T.Ogino, T.Kinoshita
  • Journal Title: Int.J.Radiat.Oncol.Biol.Phys. Volume: 79(5) Issue: 5 Pages: 1479-1486
  • DOI: 10.1016/j.ijrobp.2009.12.048
  • Peer Reviewed
• [Journal Article] Proton dose distribution measurements using a MOSFET detector with a simple dose-weighted correction method for LET effects (2011)
  • Author(s): R Kohno
  • Journal Title: J. Appl. Clin. Med. Phys. Volume: 12 Pages: 326-337
  • Peer Reviewed
• [Journal Article] Clinical implementation of a GPU-based simplified Monte Carlo method for treatment planning system of proton beam therapy (2011)
  • Author(s): R Kohno
  • Journal Title: Phys. Med. Biol. Volume: 56 Issue: 22 Pages: N287-N294
  • DOI: 10.1088/0031-9155/56/22/n03
  • Peer Reviewed
• [Presentation] In Vivo Dosimetry of An Anthropomorphic Phantom by Using the RADPOS System for Proton Beam Therapy (2015)
  • Author(s): R Kohno, H Yamaguchi, K Motegi, K Hotta, S Nishioka, T Dohmae, T Akimoto
  • Organizer: 57th AAPM
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2015-07-12 – 2015-07-16
• [Presentation] Verification of the Simplified Monte Carlo Method for Simulation in An Inhomogeneous Phantom (2015)
  • Author(s): S Mizutani, Y Takada, R Kohno, K Hotta, T Akimoto
  • Organizer: 57th AAPM
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2015-07-12 – 2015-07-16
• [Presentation] Development of Dose Monitor Unit Calculation Using Clarkson Integration for Proton Beam Therapy Using Beam-Wobbling System (2015)
  • Author(s): Y Nagata, R Kohno, Y Takada, K Hotta, H Yamaguchi, T Akimoto
  • Organizer: 57th AAPM
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2015-07-12 – 2015-07-16
• [Presentation] Development of dose-calibration-factor calculation using Clarkson integration for proton therapy using beam-wobbling system (2015)
  • Author(s): Yuki Nagata, Ryosuke Kohno, Kenji Hotta, Hienori Yamaguchi and Yoshihisa Takada
  • Organizer: 109th JSMP
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-19
• [Presentation] Evaluation of the RADPOS 4-D in-vivo dosimetry system for Clinical Application [2] (2015)
  • Author(s): Hienori Yamaguchi, Ryosuke Kohno, Kana, Motegi, Fumiya Tanaka, Tetsuo Kawaguchi and Tetsuo Akimoto
  • Organizer: 109th JSMP
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-16
• [Presentation] 臨床応用に向けたRADPOS 4-D in-vivo dosimetryシステム (2014)
  • Author(s): 河野良介、山口秀徳、茂木佳菜、秋元哲夫
  • Organizer: JASTRO 27th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-12-12
• [Presentation] 陽子線治療におけるワブラー照射法に対する患者校正値算出法の開発 (2014)
  • Author(s): 永田裕規、河野良介、堀田健二、山口秀徳、高田義久
  • Organizer: JASTRO 27th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-12-12
• [Presentation] 陽子線治療に対する臨床応用に向けたRADPOS性能評価 (2014)
  • Author(s): 山口秀徳、河野良介、茂木佳菜、秋元哲夫
  • Organizer: JASTRO 27t
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-12-11
• [Presentation] 国立がん研究センター東病院 施設紹介 (2014)
  • Author(s): 河野良介、道前武、片岡昌治、篠田正樹
  • Organizer: 第１回粒子線治療施設 運転・維持管理ワークショップ
  • Place of Presentation: 放射線医学総合研究所
  • Year and Date: 2014-10-03
• [Presentation] 国立がん研究センター東病院に於ける陽子線治療施設の不具合事例お良い対応 (2014)
  • Author(s): 道前武、河野良介、片岡昌治、篠田正樹
  • Organizer: 第１回粒子線治療施設 運転・維持管理ワークショップ
  • Place of Presentation: 放射線医学総合研究所
  • Year and Date: 2014-10-03
• [Presentation] PPLIZATION OF DOSE KERNEL CALCULATION USING ASIMPLIFIED MONTE CALRO METHOD TO TREATMENT PLANNING FOR IMPT (2014)
  • Author(s): S Mizutani, Y Takada, R Kohno, K Hotta, T Akimoto
  • Organizer: 7th KJMP
  • Place of Presentation: Busan, Korea
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 陽子線治療用ラインスキャニングシステムの開発 (2014)
  • Author(s): 河野良介・堀田健二・水谷昌平・宮岸朋子・茂木佳菜・道前武・酒井和幸・橘英伸・西尾禎治・秋元哲夫・立川俊樹・浅羽徹・井上純一・越智俊昭・山田学・宮永裕樹
  • Organizer: 国立がん研究センター研究所 国立国際医療研究センター研究所２０１４年度合同リトリート
  • Place of Presentation: セミナー常総
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] Novel Technique for Cynamic Lung Ventilation Imaging Based on Aide Coverage 4D CT (2014)
  • Author(s): B Neal, J Kipritidis, R Kohno, S Matsumoto, T Yamamoto
  • Organizer: AAPM 56th
  • Place of Presentation: Austin, USA
  • Year and Date: 2014-07-24
• [Presentation] Dose kernel calculation using a simplified Monte Carlo method for spot scanned proton therapy (2014)
  • Author(s): S. Mizutani, R. Kohno, K. Hotta, Y. Takada, R. Tansho, T. Akimoto
  • Organizer: 53rd PTCOG
  • Place of Presentation: Shanghai, China
  • Year and Date: 2014-06-08 – 2014-06-14
• [Presentation] Evaluation of the RADPOS 4-D in-vivo dosimetry system (2014)
  • Author(s): H Yamaguchi, R Kohno, T Akita, Y Nagata, K Hotta, T Miyagishi, T Akimoto
  • Organizer: JSMP 107th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-13
• [Presentation] Dose linearity in respiratory-gated proton therapy (2014)
  • Author(s): H Asai, S Kito, T Kawaguchi, R Kohno, T Akimoto
  • Organizer: JSMP 107th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-10
• [Presentation] Study for longitude position dependence to CT-value in 320-row CBCT Volume Scan (2014)
  • Author(s): R Hirai, R Kohno, S Matsumoto, K Motegi, K Hotta, Y Matsuzaki, S Kito, T Akimoto
  • Organizer: JSMP 107th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-10
• [Presentation] 放射線腫瘍医教育システムの確立に向けて-放射線治療を支える「医学物理士」の効用- (2013)
  • Author(s): 河野良介
  • Organizer: JASTRO 26th
  • Place of Presentation: リンクステーションホール青森
  • Year and Date: 2013-10-20
  • Invited
• [Presentation] Research Approach towards high precision and efficiency proton beam therapy at National Cancer Center Hospital East (2013)
  • Author(s): Ryosuke Kohno, Kenji Hotta, Yuka Matsuzaki, Tomoko Miyagishi, Kana Motegi, Ryohei Tansho, Shohei Mizutani, Hidenori Yamaguchi, Ryuta Hirai, Tomohito Suzuki, Teiji Nishio and Tetsuo Akimoto
  • Organizer: 第１０６回日本医学物理学会
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-09-18
• [Presentation] Line Scanning System for Proton Therapy in National Cancer Center Hosipital East (2013)
  • Author(s): Yuka Matsuzaki, Ryosuke Kohno, Kenji Hotta, Teiji Nishio, Tomoko Miyagishi, Tetsuo Akimoto, Toshiki Tachikawa, Tohru Asaba, Junichi Inoue, Toshiaki Oci, Manabu Yamada, Hiroki Miyanaga and Shoji Kataoka
  • Organizer: JSMP 106th
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-09-18
• [Presentation] Development of a convenient and high-accuracy Treatment Planning System for proton therapy (2013)
  • Author(s): Kenji Hotta, Ryosuke Kohno, Tomoko Miyagishi, Yuka Matsuzaki, Ryohei Tansho, Hidenori Yamaguchi, Tomohito Suzuki and Tetsuo Akimoto
  • Organizer: JSMP 106th
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-09-18
• [Presentation] Verification for accuracy of calculated dose calibration factors for the clinical case in proton therapy (2013)
  • Author(s): Hidenori Yamaguchi, Yoshihisa Takada, Ryosuke Kohno, Kenji Hotta, Tomoko Miyagishi, Ryohei Tansho, Shohei Mizutani, Tetsuo Akimoto
  • Organizer: JSMP 106th
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-09-18
• [Presentation] Fast dose calculation method using non-Gaussianinitial beam model for beamaobbling system (2013)
  • Author(s): Ryohei Tansho, Yoshihisa Takada, Ryosuke Kohno, Kenji Hotta and Shohei Mizutani
  • Organizer: JSMP 106th
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-09-18
• [Presentation] Commissioning of new proton treatment planning system in NCCHE (2013)
  • Author(s): Tomoko Miyagishi, Ryosuke Kohno, Kenji Hotta, Yuka Matsuzaki, Kana Motegi, Ryohei Tansho, Shohei Mizutani, Hidenori Yamaguchi, Ryuta Hirai, Tomohito Suzuki, Teiji Nishio and Tetsuo Akimoto
  • Organizer: JSMP 106th
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-09-18
• [Presentation] 陽子線治療におけるモンテカルロ線量計算の必要性とその応用 (2013)
  • Author(s): 河野良介、堀田健二、宮岸朋子、松崎有華、茂木佳菜、秋元哲夫
  • Organizer: 第１０回日本粒子線治療臨床研究会
  • Place of Presentation: 名古屋市立西部医療センター
  • Year and Date: 2013-09-14
• [Presentation] 局所限局性前立腺癌に対する陽子線治療による寡分割照射法の初期経験 (2013)
  • Author(s): 秋元哲夫、茂木厚、小野澤正勝、戸嶋雅道、荒平聡子、全田貞幹、河野良介、堀田健二、松崎有華、西尾禎治
  • Organizer: 第１０回日本粒子線治療臨床研究会
  • Place of Presentation: 名古屋市立西部医療センター
  • Year and Date: 2013-09-14
• [Presentation] Commissioning of the line scanning method proton beam delivery system at National Cancer Center Hospital East (2013)
  • Author(s): Ryosuke Kohno, Kenji Hotta, Yuka Matsuzaki, Teiji Nishio, Tetsuo Akimoto, Toshiki Tachikawa, Toru Asaba, Junichi Inoue, Toshiaki Ochi, Manabu Yamada, Hiroki Miyanaga
  • Organizer: PTCOG 52
  • Place of Presentation: Essen, Germany
  • Year and Date: 2013-06-02 – 2013-06-08
• [Presentation] Development of beam scanning control system for proton radiation therapy (2013)
  • Author(s): J. Inoue, T. Ochi, T. Morita, T. Tachikawa, T. Asaba, R. Kohno, K. Hotta, Y. Matsuzaki, T. Nishio, T Akimoto
  • Organizer: PTCOG 52
  • Place of Presentation: Essen, Germany
  • Year and Date: 2013-06-02 – 2013-06-08
• [Presentation] A comparative study of dose distribution in proton spot scanning and that in patch irradiation (2013)
  • Author(s): Shohei Mizutani, Yoshihisa Takada, Ryohei Tansyo, Ryuichi Kawai, Masaki Tanabe, Ryo Yachidate, Jahan Israt, Tetsuo Akimoto, Ryosuke Kohno and Kenji Hotta
  • Organizer: JSMP 105th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-04-13
• [Presentation] The positional accuracy of robotic arm treatment bed using Micrometer Drive (2013)
  • Author(s): Tsunemichi Akita, Yuka Matsuzaki, Satoe Fukuhara, Tatsuya Mogaki, Kenji Hotta, Youhei Takeda, Isamu Maeshima, Masaki Shinoda, Atsushi Sakamoto and Ryosuke Kohno
  • Organizer: JSMP 105th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-04-12
• [Presentation] Evaluation of the phantom for cone-beam CT to create CT number-linear stopping power ratio conversion table for proton treatment (2013)
  • Author(s): Ryuta Hirai, Ryosuke Kohno,Shinnosuke Matsumoto, Kana Matsubara, Kenji Hotta, Yuka Matsuzaki, Satoe Fukuhara, Akiko Shiwa, Testsuo Akimoto and Hidetoshi Saitoh
  • Organizer: JSMP 105th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-04-12
• [Presentation] Examination of the daily QA method of the isocenter positions in In-room CT and orthogonal DR (2013)
  • Author(s): Tatsuya Mogaki, Satoe Fukuhara, Tsunemichi Akita, Youhei Takeda, Kenji Hotta, Yuka Matsuzaki, Isamu Maeshima, Masaki Shinoda, Atsushi Sakamoto and Ryosuke Kohno
  • Organizer: JSMP 105th
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-04-12
• [Presentation] フィルムによる陽子線線量測定の為の簡便校正法の開発 (2012)
  • Author(s): 西岡史絵、堀田健二、松原佳菜、江頭祐亮、河野良介
  • Organizer: JSMP 103rd
  • Place of Presentation: パシフィコ横浜
• [Presentation] 320列CTに対する陽子線治療計画用CT値―線阻止能比変換テーブル測定 (2012)
  • Author(s): 平井隆太、堀田健二、鈴木庸次郎、菅原光、松原佳菜、堀田健二、志晃子、渋谷真二
  • Organizer: JSMP 103rd
  • Place of Presentation: パシフィコ横浜
• [Presentation] 陽子線がん治療における体内「線量分布」を考える-粒子線治療における医学物理の必要性- (2012)
  • Author(s): 河野良介、堀田健二、秋元哲夫
  • Organizer: 第４１回放射線による制癌シンポジウム
  • Place of Presentation: 健康文化村カルチャーリゾートフェストーネ
  • Invited
• [Presentation] CCD＋蛍光板を使った陽子線スポットスキャニング照射のための線量分布測定器の開発 (2012)
  • Author(s): 歳藤利行、林健佑、柴田洋希、安井啓祐、田中堅一郎、大町千尋、荻野浩幸、西尾禎治、河野良介、堀田健二、山崎淳、鈴木博之
  • Organizer: JSMP 103rd
  • Place of Presentation: パシフィコ横浜
• [Presentation] Direct Point Dose Verification Using IGRT for Actual Beam Delivery (2012)
  • Author(s): K Matsubara, R Kohno, S Nishioka, T Shibuya, T Ariji, T Akimoto, H Saitoh
  • Organizer: AAPM54th
  • Place of Presentation: Charlotte（アメリカ）
• [Presentation] Dose Calculation Model Using the Simplified Monte Carlo Method with An Initial Beam Model Adapted to a Beam-Wobbling System (2012)
  • Author(s): R Tansho, R Kohno, Y Takada, K Hotta, Y Hara, K Nagafuchi, Y Suzuki, T Akimoto
  • Organizer: AAPM54th
  • Place of Presentation: Charlotte（アメリカ）
• [Presentation] ワブラー法における入射ビームモデルの改善と簡易モンテカルロ法を使った線量分布計算の精度検証 (2012)
  • Author(s): 丹正亮平、河野良介、高田義久、堀田健二、水谷昌平、田邊雅貴
  • Organizer: JSMP 104th
  • Place of Presentation: つくば国際会議場
• [Presentation] 患者プランQAを目的とした陽子線治療における線量計算法の検証 (2012)
  • Author(s): 宮阪遼平、堀田健二、河野良介、丹正亮平、松原佳菜、平井隆太、松崎有華、秋元哲夫、齋藤秀敏
  • Organizer: JSMP 104th
  • Place of Presentation: つくば国際会議場
• [Presentation] 国立がん研究センター東病院における陽子線治療システムのQA実施とその評価 (2012)
  • Author(s): 鈴木博之、河野良介、西岡史絵、堀田健二、太田隆一、霜重拓也、坂本篤信、渡邊徹、川口鉄朗、佐田野圭吾、渡邊秀樹、松崎有華、篠田正樹、秋元哲夫
  • Organizer: JSMP 104th
  • Place of Presentation: つくば国際会議場
• [Presentation] 陽子線治療の高精度化並びに高効率化に向けた患者校正計算法の開発 (2012)
  • Author(s): 河野良介、高田義久、堀田健二、松崎有華、全田貞幹、荒平聡子、戸嶋雅道、茂木厚、河島光彦、秋元哲夫
  • Organizer: JASTRO 25t
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 頭頸部IMRTにおける体系変化対策前後のsetup-error推移 (2012)
  • Author(s): 上田隆司、河野良介、松原佳菜、有路貴樹、田中史弥、伊藤由紀、渋谷俊之、芳田充博、河島光彦
  • Organizer: JASTRO 25th
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 頭頸部がんの陽子線治療計画に対する簡易モンテカルロ法による線量計算 (2011)
  • Author(s): 河野良介
  • Organizer: JSMP 101st
  • Place of Presentation: パシフィコ横浜
• [Presentation] 陽子線治療計画に対するGPGPU対応モンテカルロ線量計算法の開発 (2011)
  • Author(s): 河野良介
  • Organizer: JASTRO 24th
  • Place of Presentation: 神戸ポートピアホテル
• [Book] 放射線計測学 (2015)
  • Author(s): 納冨昭弘
  • Total Pages: 330
  • Publisher: 国際文献社
• [Book] 外部放射線治療における水吸収線量の標準計測法 (2012)
  • Author(s): 日本医学物理学会編
  • Total Pages: 255
  • Publisher: 通商産業研究社
• [Book] X線線量計算の不均質補正に関する医学物理ガイドライン (2011)
  • Author(s): 水野秀之
  • Total Pages: 95
  • Publisher: Jpn. Soc. Med. Phys.
• [Remarks] 河野 良介
  • URL: http://www.ncc.go.jp/jp/ncce/rcio/research/ptd/rkohno.html
• [Patent(Industrial Property Rights)] 粒子線照射法における線量分布の最適化プログラム、及び装置 (2014)
  • Inventor(s): 河野良介
  • Industrial Property Rights Holder: 河野良介
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-116974
  • Filing Date: 2014-06-05