Challenge in the assessment of the injured donor lungs and its treatment using an ex vivo lung perfusion
Project/Area Number |
23689063
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Thoracic surgery
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Research Institution | Kyoto University |
Principal Investigator |
FENGSHI Chen 京都大学, 医学(系)研究科(研究院), 助教 (00452334)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
Keywords | 肺移植 / 体外肺潅流 / 傷害肺 / 蘇生 / 臓器保存 / ドナー肺 |
Research Abstract |
To encounter the donor shortage in lung transplantation, it is necessary to utilize the injured donor lungs, such as marginal donor lungs. It is essential to assess the quality of the injured donor lungs for using such injured lungs safely. Thus, we performed the study in which we assess the function of the donor lungs preoperatively using an ex vivo lung perfusion (EVLP) and even treat the injured lungs during EVLP. Firstly, we demonstrated that we could assess the function of the donor lungs accurately using EVLP. Secondly, the group with a drug inhalation showed a better lung function than the group without a drug inhalation, suggesting the possibility of treatment of the injured donor lungs during EVLP.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Protective effect of plasmin in marginal donor lungs in an ex vivo lung perfusion model2013
Author(s)
Motoyama H, Chen F, Ohsumi A, Hijiya K, Okita K, Nakajima D, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
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Journal Title
J Heart Lung Transplant
Volume: 32(5)
Issue: 5
Pages: 505-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Reconditioning lungs donated after cardiac death using short-term hypothermic machine perfusion2012
Author(s)
Nakajima D, Chen F, Okita K, Motoyama H, Hijiya K, Ohsumi A, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
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Journal Title
Transplantation 2012
Volume: 94(10)
Issue: 10
Pages: 999-1004
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Reconditioning lungs donated after cardiac death using short-term hypothermic machine perfusion2012
Author(s)
Nakajima D, Chen F, Okita K, Motoyama H, Hijiya K, Ohsumi A, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H.
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Journal Title
Transplantation
Volume: Nov 27;94(10)
Pages: 999-1004
Related Report
Peer Reviewed
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[Journal Article] Protective Effect of Prerecovery Surfactant Inhalation on Lungs Donated After Cardiac Death in a Canine Lung Transplantation Model2012
Author(s)
Ohsumi A, Chen F, Sakamoto J, Nakajima D, Hijiya K, Motoyama H, Okita K, Horita K, Kikuchi R, Kojima F, Sato T, Yamada T, Sakai H, Bando T, Date H
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Journal Title
J Heart Lung Transplant
Volume: Oct;31(10)
Issue: 10
Pages: 1136-42
DOI
Related Report
Peer Reviewed
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[Journal Article] Short-term outcome in living donors for lung transplantation: the role of preoperative computer tomographic evaluations of fissures and vascular anatomy2012
Author(s)
Chen F, Fujinaga T, Shoji T, Kubo T, Sonobe M, Sato M, Aoyama A, Sato T, Sakai H, Bando T, Date H
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Journal Title
Transpl Int
Volume: Jul;25(7)
Issue: 7
Pages: 732-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of pre-procurement ventilation on lungs donated after cardiac death in a canine lung transplantation model2011
Author(s)
Sakamoto J, Chen F, Yamada T, Nakajima D, Ohsumi A, Kikuchi R, Zhao X, Fujinaga T, Shoji T, Sakai H, Bando T, Date H
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Journal Title
Transplantation
Volume: 92(8)
Pages: 864-70
Related Report
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[Journal Article] Normothermic ex vivo lung perfusion in clinical lung transplantation2011
Author(s)
Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, Sato M, Laratta J, Azad S, Madonik M, Chow CW, Chaparro C, Hutcheon M, Singer LG, Slutsky AS, Yasufuku K, De Perrot M, Pierre AF, Waddell TK, Keshavjee S
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Journal Title
N Eng J Med
Volume: 364
Pages: 1431-40
Related Report
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[Presentation] Correlation of physiological data at ex vivo lung perfusion and reperfusion in a rat ischemia-reperfusion model using plasmin2014
Author(s)
Motoyama H, Chen F, Hijiya K, Takahashi M, Ohata K, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
Abstract#692, 34th Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
San Diego
Related Report
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[Presentation] Length of the agonal phase in donors after cardiac death influences donor lung function after reperfusion in a rat model2014
Author(s)
H ijiya K, Chen F, K. Takahashi M, Ohata K, Kondo T, Motoyoma H, Ohsumi A, Nakajima D, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
Abstract#246, 34th Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
San Diego
Related Report
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[Presentation] Protective effect of beta-2 adrenoreceptor agonist inhalation during ex vivo lung perfusion2014
Author(s)
Kondo T, Chen F, K. Takahashi M, Ohata K, Motoyoma H, Hijiya K, Ohsumi A, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
Abstract#114, 34th Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
San Diego
Related Report
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[Presentation] Protective Effect of Plasmin in Marginal Donor Lungs in an Ex Vivo Lung Perfusion Model. Abstract#6802013
Author(s)
H. Motoyama, F. Chen, A. Ohsumi, K. Hijiya, K. Okita, K. Kondo, D. Nakajima, J. Sakamoto, T. Yamada, A. Aoyama, M. Sato, T. Bando, H. Date
Organizer
33th Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
Montreal
Related Report
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[Presentation] Ex Vivo Lung Perfusion (EVLP)中のplasmin投与によるドナー肺の機能改善効果。2013
Author(s)
本山秀樹、陳 豊史、大角明宏1,土屋恭子1,尾北賢治1,近藤健1,阪本仁1,中島大輔1,山田徹1,佐藤雅昭1,青山晃博1,佐藤寿彦1,園部誠1,大政貢1,板東徹伊達洋至
Organizer
第30回日本呼吸器外科学会総会
Place of Presentation
名古屋
Related Report
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[Presentation] Protective Effect of Plasmin in Marginal Donor Lungs in an Ex Vivo Lung Perfusion Model2013
Author(s)
Motoyama, F. Chen, A. Ohsumi, K. Hijiya, K. Okita, K. Kondo, D. Nakajima, J. Sakamoto, T. Yamada, A. Aoyama, M. Sato, T. Bando, H. Date.
Organizer
33th Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
Montreal
Related Report
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[Presentation] Reconditioning of lungs donated after cardiac deathwith short-term hypothermic machine perfusion2012
Author(s)
Nakajima D, Chen F, Okita K, Motoyama H, Hijiya K, Ohsumi A, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
CO10.02 XXIV International Congress of The Transplantation Society Berlin
Place of Presentation
Germany
Related Report
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[Presentation] Protective effect of plasmin for the non-heparinized donor lungs after cardiac death2012
Author(s)
Motoyama H, Chen F, Ohsumi A, Hijiya K, Okita K, Nakajima D, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
PO10.36 XXIV International Congress of The Transplantation Society Berlin
Place of Presentation
Germany
Related Report
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[Presentation] Prophylactic Surfactant Inhalation Attenuates Warm Ischemic Injury in Rat Lungs from Donation after Cardiac Death Donors2012
Author(s)
Ohsumi A, Chen F, Nakajima D, Sakamoto J, Kobayashi M, Yamada T, Fujinaga T, Shoji T,Sakai H, Bando T, Date H
Organizer
CO33.08 XXIV International Congress of The Transplantation Society Berlin
Place of Presentation
Germany
Related Report
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[Presentation] Continuous Transcutaneous Carbon Dioxide Monitoring in Living-Donor Lobar Lung Transplantation2012
Author(s)
Chen F, Ohsumi A, HIjiya K, Okita K, Motoyama H, Sakamoto J, Nakajima D, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
International Congress of The Transplantation Society
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] Reconditioning of lungs donated after cardiac deathwith short-term hypothermic machine perfusion2012
Author(s)
Nakajima D, Chen F, Okita K, Motoyama H, Hijiya K, Ohsumi A, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
International Congress of The Transplantation Society
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] Protective effect of plasmin for the non-heparinized donor lungs after cardiac death2012
Author(s)
Motoyama H, Chen F, Ohsumi A, Hijiya K, Okita K, Nakajima D, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
International Congress of The Transplantation Society
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] Prophylactic Surfactant Inhalation Attenuates Warm Ischemic Injury in Rat Lungs from Donation after Cardiac Death Donors2012
Author(s)
Ohsumi A, Chen F, Nakajima D, Sakamoto J, Kobayashi M, Yamada T, Fujinaga T, Shoji T,Sakai H, Bando T, Date H
Organizer
International Congress of The Transplantation Society
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] Therapeutic Effect of Surfactant Inhalation on Lungs Donated after Cardiac Death in a Canine Lung Transplantation Model2012
Author(s)
5. Akihiro Ohsumi, Fengshi Chen, Jin Sakamoto, Daisuke Nakajima, Kyoko Hijiya, Hideki Motoyama, Kenji Okita, Kenta Horita, Ryutaro Kikuchi, Hiroaki Sakai, Toru Bando, and Hiroshi Date
Organizer
32th Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
Prague
Related Report
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