Effect of analgesic adjuvant on TRP channels

Research Project

Project/Area Number	23689068
Research Category	Grant-in-Aid for Young Scientists (A)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Kyushu University
Principal Investigator	KARASHIMA Yuji 九州大学, 大学病院, 講師 (80380434)
Project Period (FY)	2011-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000) Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2011: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Keywords	TRPチャネル / 鎮痛薬 / パッチクランプ
Research Abstract	The purpose of this study was to elucidate the effect of analgesics and adjuvant analgesics on TRP channels which are reported to be participated in pain by using the patch clamp technique. Acetaminophen, antiepileptic drugs (gabapentin, clonazepam), and pregabalin which are frequently used for chronic pain and cancer pain were evaluated. As for acetaminophen, its metabolites acted on TRPA1 but not on TRPV1. Antiepileptic drugs such as gabapentin and clonazepam, and pregabalin have no direct action on both TRPA1 and TRPV1.

Report

(4 results)