Effect of analgesic adjuvant on TRP channels
| Project/Area Number |
23689068
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Keywords | TRPチャネル / 鎮痛薬 / パッチクランプ |
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| Research Abstract |
The purpose of this study was to elucidate the effect of analgesics and adjuvant analgesics on TRP channels which are reported to be participated in pain by using the patch clamp technique. Acetaminophen, antiepileptic drugs (gabapentin, clonazepam), and pregabalin which are frequently used for chronic pain and cancer pain were evaluated.
As for acetaminophen, its metabolites acted on TRPA1 but not on TRPV1. Antiepileptic drugs such as gabapentin and clonazepam, and pregabalin have no direct action on both TRPA1 and TRPV1.
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Report
(4 results)
Research Products
(1 results)
