To reveal the molecular mechanism of deafness from the point of actin cytoskeleton
| Project/Area Number |
23689069
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Juichi 京都大学, 大学院医学研究科, 教授 (90176339)
KATSUNO Tatsuya 京都大学, 大学院医学研究科, 特定研究員 (90527665)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2011: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | 耳科学 / 難聴 / アクチン / 不動毛 / 聴覚 / 不動毛（聴毛） / 細胞骨格 |
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| Research Abstract |
We have identified TRIOBP, a structural molecule as a response molecule to harmonize actin cytoskeleton in the hair cells of the inner ear. Especially, TRIOBP is necessary to generate rootlets of hair cell stereocilia, the actin based protrusion that detect the sound stimuli and transduce. There are three kinds of isoform of this molecule, and we are investing of the isoform specific function. Fluorescence-detection size- exclusion chromatography and immunoprecipitation showed us the existence of TRIOBP complex on each isoform. Moreover, we have generated the isoform specific knock out mice model. We have just staring the characterization, and this would be the best model to look into the function of each isoform in vivo.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations.2014
Author(s)
Kumeta, M., Gilmore, J. L., Umeshima, H., Ishikawa, M., Kitajiri, S. I., Horigome, T., Kengaku, M., Takeyasu, K.
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Journal Title
Genes Cells
Volume: 19
Pages: 338-349
Related Report
Peer Reviewed
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