Establishment of therapeutic strategies to comprehensively control inflammation and bone destruction in arthritis
| Project/Area Number |
23689075
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | The University of Tokyo (2012-2013)
Tokyo Medical and Dental University (2011) |
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Principal Investigator |
OKAMOTO Kazuo 東京大学, 医学(系)研究科(研究院), 助教 (00436643)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2011: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
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| Keywords | 骨代謝 / 関節リウマチ / 破骨細胞 / 骨芽細胞 / Th17細胞 |
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| Research Abstract |
The pathogenesis of bone destruction associated with chronic inflammation such as rheumatoid arthritis relied on two phases; abnormal immune responses and dysregulation of bone system. I've found that the transcription regulatory factor IkappaBzeta regulates Th17 development and is expressed in several bone cells. Thus, in this study, I attempted to determine the potential of IkappaBzeta as a therapeutic target for the treatment of inflammation-associated bone destruction, using genetically modified mice. Furthermore, I tried to identify a novel target cell/ factor that regulates both inflammation and bone destruction in arthritis. This study may provide the molecular basis for a new therapeutic strategy to block not only Th17-mediated inflammation but also osteoclastic bone destruction.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014
Author(s)
Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
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Journal Title
Nature Medicine
Volume: 20
Issue: 1
Pages: 62-68
DOI
Related Report
Peer Reviewed / Open Access
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