The roles of GABA on development and function of taste bud cells
| Project/Area Number |
23689076
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
YOSHIDA Ryusuke 九州大学, 歯学研究科(研究院), 講師 (60380705)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 味細胞 / GABA / 遺伝子改変マウス / 味覚 / 発達 / Cl-濃度 / Cl^-濃度 |
|---|
| Research Abstract |
This study has demonstrated that (1) GABA may not have a pivotal role in development of taste buds or taste cells and in innervation of gustatory nerve fibers to taste buds, (2) GABA may be released from a subset of taste cells, possibly Type III cells, by depolarization of these cells, (3) intracellular Cl- concentration in taste cells may be very high therefore GABA would induce excitatory responses in these taste cells. These results suggest that GABA may play some roles in modulation of taste sensitivities in taste buds.
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Report
(4 results)
Research Products
(89 results)
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[Presentation] 味覚情報伝達におけるATPの役割2011
Author(s)
吉田竜介、仁木真由、村田芳博、二ノ宮裕三
Organizer
生理研研究会「情報伝達物質としてのプリンの意義」
Place of Presentation
岡崎コンベンションセンター(岡崎)
Year and Date
2011-10-21
Related Report
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[Presentation] Involvement of T1R-independent receptors in detection of umami taste in mice2011
Author(s)
Kusuhara Y, Yasumatsu K, Ohkuri T, Yoshida R, Boehm U, Voigt A, Hubner S, Maeda K, Meyerhof W, Ninomiya Y
Organizer
ECRO 2011
Place of Presentation
Manchester, UK
Year and Date
2011-09-08
Related Report
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