Neural and genetic bases of higher cognitive functions and their plasticity

• Project/Area Number: 23700306
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cognitive science
• Research Institution: Tohoku University
• Principal Investigator: TAKEUCHI Hikaru 東北大学, 加齢医学研究所, 准教授 (50598399)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 高次認知機能 / 神経系 / 脳イメージング / 可塑性 / 認知訓練 / 認知科学 / 遺伝的多型

Research Abstract

We investigated the neural mechanisms of individual differences of higher order cognitive functions and effects of higher order cognitive training on neural mechanisms. Through longitudinal studies, we revealed the effects of training on processing speed and training on working memory. Through cross-sectional studies, we revealed neural mechanisms underlying individual differences of higher cognitive functions such as working memory, general intelligence, and creativity as well as cognitive measures that play importantroles in psychiatric disorders and subjective well-being.

Research Products

• [Journal Article] White matter structures associated with empathizing and systemizing inyoung adults (2013)
  • Author(s): Takeuchi H, Taki Y, Thyreau B, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R
  • Journal Title: Neuroimage Volume: 77(15) Pages: 222-236
  • URL: http://dx.doi.org/10.1016/j.neuroimage.2013.04.004
  • Peer Reviewed
• [Journal Article] Anatomical correlates of quality of life: Evidence from voxel-based morphometry (2013)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sassa Y, Sekiguchi A, Kotozaki Y, Nakagawa S, Nagase T, Miyauchi CM, Kawashma R
  • Journal Title: Human Brain Mapping Volume: (In press)
  • URL: http://dx.doi.org/10.1002/hbm.22294
  • Peer Reviewed
• [Journal Article] Anatomical correlates of self-handicapping tendency (2013)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R
  • Journal Title: Cortex Volume: 49(4) Pages: 1148-1154
  • URL: http://dx.doi.org/10.1016/j.cortex.2013.01.014
  • Peer Reviewed
• [Journal Article] White matter structures associated with emotional intelligence: evidence from diffusion tensor imaging (2013)
  • Author(s): Takeuchi H, Taki Y, Sassa Y, HashizumeH, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R
  • Journal Title: Human Brain Mapping Volume: 34(5) Pages: 1025-1034
  • URL: http://dx.doi.org/10.1002/hbm.21492
  • Peer Reviewed
• [Journal Article] White matter structures associated with empathizing and systemizing in young adults. (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Neuroimage Volume: in press Pages: 222-236
  • DOI: 10.1016/j.neuroimage.2013.04.004
  • Peer Reviewed
• [Journal Article] Anatomical correlates of quality of life: Evidence from voxel-based morphometry. (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Human Brain Mapping Volume: in press
  • Peer Reviewed
• [Journal Article] Anatomical correlates of self-handicapping tendency (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Cortex Volume: in press Issue: 4 Pages: 1148-1154
  • DOI: 10.1016/j.cortex.2013.01.014
  • Peer Reviewed
• [Journal Article] Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry. (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Brain Structure and Function Volume: in press Issue: 1 Pages: 71-83
  • DOI: 10.1007/s00429-012-0485-3
  • Peer Reviewed
• [Journal Article] Effects of working memory-training on functional connectivity and cerebral blood flow during rest. (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Cortex Volume: in press Issue: 8 Pages: 2106-2125
  • DOI: 10.1016/j.cortex.2012.09.007
  • Peer Reviewed
• [Journal Article] Brain structures associated with executive functions during everyday events in a non-clinical sample. (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Brain Structure and Function Volume: in press Issue: 4 Pages: 1017-1032
  • DOI: 10.1007/s00429-012-0444-z
  • Peer Reviewed
• [Journal Article] Associations among imaging measures (2): The association between gray matter concentration and task-induced activation changes. (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Human Brain Mapping Volume: in press Issue: 1 Pages: 185-198
  • DOI: 10.1002/hbm.22167
  • Peer Reviewed
• [Journal Article] White matter structures associated with emotional intelligence: evidence from diffusion tensor imaging. (2013)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Human Brain Mapping Volume: 34 Issue: 5 Pages: 1025-1034
  • DOI: 10.1002/hbm.21492
  • Peer Reviewed
• [Journal Article] Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry (2012)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Hashizume H, Nakagawa S, Kunitoki K, Sassa Y, Kawashima R
  • Journal Title: Brain Structure and Function Volume: (In press)
  • URL: http://dx.doi.org/10.1007/s00429-012-0485-3
  • Peer Reviewed
• [Journal Article] Effects of working memory-training on functional connectivity and cerebral blood flow during rest (2012)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R
  • Journal Title: Cortex Volume: (In press)
  • URL: http://dx.doi.org/10.1016/j.cortex.2012.09.007
  • Peer Reviewed
• [Journal Article] A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness (2012)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Hashizume H, Nakagawa S, Kunitoki K, Sassa Y, Kawashima R
  • Journal Title: Neuroimage Volume: 63(3) Pages: 1119-1126
  • URL: http://dx.doi.org/10.1016/j.neuroimage.2012.08.037
  • Peer Reviewed
• [Journal Article] Brain structures associated with executive functions during everyday events in a non-clinical sample (2012)
  • Author(s): Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R
  • Journal Title: Brain Structure and Function Volume: (In press)
  • URL: http://dx.doi.org/10.1007/s00429-012-0444-z
  • Peer Reviewed
• [Journal Article] Associations among imaging measures (2): The association between gray matter concentration and task-inducedactivation changes (2012)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sassa Y, Sekiguchi A, Kotozaki Y, Nakagwa S, Nagase T, Miyauch CM, Kawashima R
  • Journal Title: Human Brain Mapping Volume: (In press)
  • URL: http://dx.doi.org/10.1002/hbm.22167
  • Peer Reviewed
• [Journal Article] Effects of processing speed training on cognitive functions and neural systems.(review) (2012)
  • Author(s): Takeuchi H, Kawashima R
  • Journal Title: Reviews in the Neurosciences Volume: 23(3) Pages: 289-301
  • URL: http://dx.doi.org/10.1515/revneuro-2012-0035
• [Journal Article] The association between resting functional connectivity and creativity (2012)
  • Author(s): Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R
  • Journal Title: Cerebral Cortex Volume: 22(12) Pages: 2921-2929
  • Peer Reviewed
• [Journal Article] Regional gray and white matter volume associated with Stroop interference: Evidence from voxel-based morphometry (2012)
  • Author(s): Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R
  • Journal Title: Neuroimage Volume: 59(3) Pages: 2899-2907
  • URL: http://dx.doi.org/10.1016/j.neuroimage.2011.09.064
  • Peer Reviewed
• [Journal Article] A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness. (2012)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Neuroimage. Volume: 63 Issue: 3 Pages: 1119-1126
  • DOI: 10.1016/j.neuroimage.2012.08.037
  • Peer Reviewed
• [Journal Article] Effects of processing speed training on cognitive functions and neural systems. (2012)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Reviews in the neurosciences Volume: 23 Issue: 3 Pages: 289-301
  • DOI: 10.1515/revneuro-2012-0035
• [Journal Article] The association between resting functional connectivity and creativity. (2012)
  • Author(s): Hikaru Takeuchi
  • Journal Title: Cerebral Cortex Volume: 22 Issue: 12 Pages: 2921-2929
  • DOI: 10.1093/cercor/bhr371
  • Peer Reviewed
• [Journal Article] Regionalgray and whitemattervolumeassociated with Stroop interference: Evidence from voxel-basedmorphometry (2012)
  • Author(s): Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Rui Nouchi, Ai Fukushima, and Ryuta Kawashima
  • Journal Title: NeuroImage Volume: 59 Issue: 3 Pages: 2899-2907
  • DOI: 10.1016/j.neuroimage.2011.09.064
• [Journal Article] Effects of processing speed training on cognitive functions and neural systems. (2012)
  • Author(s): Hikaru Takeuchi, and Ryuta Kawashima
  • Journal Title: Reviews in the Neurosciences Volume: in press
• [Journal Article] Cerebral blood flow during rest associates with general intelligence and creativity (2011)
  • Author(s): Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R
  • Journal Title: PLoS ONE Volume: 6(9)
  • Peer Reviewed
• [Journal Article] Verbal working memory performancecorrelates with regional white matter structures in the frontoparietal regions (2011)
  • Author(s): Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R
  • Journal Title: Neuropsychologia Volume: 49(12) Pages: 3466-3473
  • Peer Reviewed
• [Journal Article] Working memory training using mental calculation impacts regional gray matter of the frontal and parietal regions (2011)
  • Author(s): Takeuchi H, Taki Y, Sassa Y, HashizumeH, Sekiguchi A, Fukushima A, KawashimaR
  • Journal Title: PLoS ONE Volume: 6(8)
  • Peer Reviewed
• [Journal Article] Effects of training of processing speed on neural systems (2011)
  • Author(s): Takeuchi H, Taki Y, Hashizume H, SassaY, Nagase T, Nouchi R, Kawashima R
  • Journal Title: Journal of Neuroscience Volume: 31(34) Pages: 12139-12148
  • URL: http://dx.doi.org/10.1523/JNEUROSCI.4611-09.2010
  • Peer Reviewed
• [Journal Article] Effects of Training of Processing Speed on Neural Systems (2011)
  • Author(s): Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, and Ryuta Kawashima
  • Journal Title: The Journal of Neuroscience Volume: 31 Issue: 34 Pages: 12139-12148
  • DOI: 10.1523/jneurosci.2948-11.2011
• [Presentation] Functional connectivity and higher order cognitive functions (2013)
  • Author(s): Takeuchi H
  • Organizer: International Symposium on Computational Brain Science -Development and Aging of the Human Brain
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2013-03-26
• [Presentation] The effects of the training of multi tasks on brain structures (Chosen for Interactive Poster) (2011)
  • Author(s): Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S,Miyauchi CM, Sassa Y, Kawashima R
  • Organizer: 17th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Quebec, Canada
  • Year and Date: 2011-06-27
• [Presentation] The effects of the training of multi tasks on brain structures (2011)
  • Author(s): Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima
  • Organizer: 17th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Quebec, Canada
• [Remarks] スタッフ紹介
  • URL: https://www.fbi.idac.tohoku.ac.jp/takeuchi/staff.html