Exact estimation of hazards under the several bias in medical research

• Project/Area Number: 23700335
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Statistical science
• Research Institution: Kyoto University
• Principal Investigator: YOSHIMURA Kenichi 京都大学, 医学研究科, 助教 (30415517)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ハザード比 / 生存時間解析 / 正確な方法 / 並び替え / 生物統計 / 臨床試験

Research Abstract

A new estimation method of exact hazard parameter using weighted permutation was developed. This method is applicable to the situation with restrictions and bias that we frequently face in medical research, and it has a much broader range of application such as the analysis of individualized medicine, and data of randomized clinical trial using dynamic treatment allocation.

Research Products

• [Journal Article] Optimal schedule of adjuvant chemotherapy with S-1 for stage III colon cancer: study protocol for a randomized controlled trial (2013)
  • Author(s): Kenichi Yoshimura
  • Journal Title: Trials Volume: 14 Issue: 1 Pages: 17-17
  • DOI: 10.1186/1745-6215-14-17
  • Peer Reviewed
• [Journal Article] Statistical issues and recommendations for noninferiority trials in oncology: a systematic review (2012)
  • Author(s): Tanaka S, Kinjo Y, Kataoka Y, Yoshimura K, Teramukai S
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 1837-47
• [Journal Article] A combination of SCC-antigen, CEA, and CA19-9 predicts positive pelvic lymph nodes and parametrial involvement in early-stage squamous cell carcinoma of the uterine cervix. (2012)
  • Author(s): Ikeda S, Yoshimura K, Onda T, Kasamatsu T, Kato T, Ishikawa M, Sasajima Y, Tsuda H
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 38 Pages: 1260-1265
• [Journal Article] Risk of cancer in patients with autoimmune pancreatitis (2012)
  • Author(s): Shiokawa M, Kodama Y, Yoshimura K, Kawanami C, Mimura J, Yamashita Y, Asada M, Kikuyama M, Okabe Y, Inokuma T, Ohana M, Kokuryu H, Takeda K, Tsuji Y, Minami R, Sakuma Y, Kuriyama K, Ota Y, Tanabe W, Maruno T, Kurita A, Sawai Y, Uza N, Wata
  • Journal Title: Am J Gastroenterology Volume: (in press)
• [Journal Article] Optimal schedule of adjuvant chemotherapy with S-1 for stage III colon cancer: study protocol for a randomized controlled trial (2012)
  • Author(s): Yoshimura K, Uehara K, Tojima Y, Kawai S, Mokuno Y, Maeda A, Kyokane T, Kobayashi S, Yoshioka Y, Nagino M
  • Journal Title: Trials Volume: (in press)
• [Journal Article] A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer (2011)
  • Author(s): Kanai M, Yoshimura K, Tsumura T et al.
  • Journal Title: Cancer Chemother Pharmacol Volume: 67 Pages: 1429-34
  • NAID: 120003238952
  • Peer Reviewed
• [Journal Article] A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer (2011)
  • Author(s): Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Sushovan G, Bharat A
  • Journal Title: Cancer Chemother Pharmacol Volume: 68 Pages: 157-64
  • NAID: 120003238951
  • Peer Reviewed
• [Journal Article] Feasibility study of adjuvant chemotherapy with S-1 plus cisplatin for gastric cancer (2011)
  • Author(s): Takahari D, Hamaguchi T, Yoshimura K, Katai H, Ito S, Fuse N, Kinoshita T, Yasui H, Terashima M, Goto M, Tanigawa N, Shirao K, Sano T, Sasako M
  • Journal Title: Cancer Chemother Pharmacol Volume: 67 Pages: 1423-8
  • Peer Reviewed
• [Journal Article] 実地医療と臨床試験 3) 臨床試験の方法論 (2011)
  • Author(s): 吉村健一
  • Journal Title: 腫瘍内科 Volume: 8 Pages: 486-95
• [Presentation] Expand Your Thinking Lecture - Biostatistics toward better communication between clinicians andbiostatisticians. (2012)
  • Author(s): Yoshimura K
  • Organizer: 5th Asia Pacific Lung Cancer Conference & 3rd International Thymic Malignancy Interest Group Annual Meeting
• [Presentation] Expand Your Thinking Lecture: Biostatistics toward better communication between clinicians and biostatisticians (2012)
  • Author(s): Kenichi Yoshimura
  • Organizer: 5th Asia Pacific Lung Cancer Conference & 3rd International Thymic Malignancy Interest Group Annual Meeting
  • Place of Presentation: Fukuoka
  • Invited
• [Presentation] An issue in interpretation of results of clinical trials with survival endpoint when Cox model assumption does not necessarily hold in personalized medicine era (2011)
  • Author(s): Yoshimura K
  • Organizer: 3rd Worldwide Innovative Networking Symposium
• [Presentation] Is median survival time difference a good measure of effectiveness in individualized medicine era? (2011)
  • Author(s): Yoshimura K, Teramukai S, Yamazaki K, Ohe Y
  • Organizer: Annual Meeting of American Society of Clinical Oncology
• [Presentation] Is median survival time difference a good measure of effectiveness in individualized medicine era? (2011)
  • Author(s): Yoshimura K, Teramukai S, Yamazaki K, Ohe Y
  • Organizer: 第9回日本臨床腫瘍学会学術集会
  • Place of Presentation: 横浜（神奈川県）
• [Presentation] Statistical issues and recommendations for noninferiority trials in oncology: A systematic review (2011)
  • Author(s): Tanaka S, Kinjo Y, Kataoka S, Matsumoto S, Yoshimura K, Teramukai S
  • Organizer: Annual Meeting of American Society of Clinical Oncology
  • Place of Presentation: Chicago（USA）
• [Presentation] An issue in interpretation of results of cancer clinical trials with survival endpoint when Cox model assumption does not necessarily hold in personalized medicine era (2011)
  • Author(s): Yoshimura K
  • Organizer: 3rd WIN Symposium
  • Place of Presentation: Paris（France）
• [Book] 誰も教えてくれなかった癌臨床試験の正しい解釈 (2011)
  • Author(s): 里見清一, 吉村健一
  • Publisher: 中外医学社
• [Book] がん検診．In: 松原望、美添泰人編. 統計応用の百科事典 (2011)
  • Author(s): 吉村健一
  • Publisher: 丸善出版