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Methodology of causal inference when an unmeasured confounder exists

Research Project

Project/Area Number 23700344
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Statistical science
Research InstitutionKinki University

Principal Investigator

CHIBA Yasutaka  近畿大学, 医学部附属病院, 講師 (80362474)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Keywords因果推論 / 統計科学
Outline of Final Research Achievements

I proposed some sensitivity analysis methods for unmeasured confounders. In addition, I discussed a relationship between two conditions that can be used to derive the bounds on which the casual effect must be included, and compared these two conditions. When an instrumental variable exists, I derived the bounds for causal effects with several populations as the standard population, by applying the concept of principal stratification.
I presented the bounds for the principal strata effect when an unmeasured confounder exists. Furthermore, I showed that principal strata effects correspond to direct and indirect effects under special assumptions including the monotonicity assumption. I derived the bound for direct and indirect effects the sensitivity analysis methods. For the derivation, I applied those for the principal strata effect.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012 2011

All Journal Article (19 results) (of which Peer Reviewed: 15 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Invited: 1 results) Book (4 results)

  • [Journal Article] A principal stratification approach for evaluating natural direct and indirect effects in the presence of treatment-induced intermediate confounding2015

    • Author(s)
      Taguri M, Chiba Y
    • Journal Title

      Statistics in Medicine

      Volume: 34 Issue: 1 Pages: 131-144

    • DOI

      10.1002/sim.6329

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Monotone confounding, monotone treatment selection and monotone treatment response2014

    • Author(s)
      Jiang Z, Chiba Y, VanderWeele TJ
    • Journal Title

      Journal of Causal Inference

      Volume: 2 Issue: 1 Pages: 1-12

    • DOI

      10.1515/jci-2012-0006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders2014

    • Author(s)
      VanderWeele TJ, Chiba Y
    • Journal Title

      Epidemiology, Biostatistics and Public Health

      Volume: 11 Issue: 2

    • DOI

      10.2427/9027

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 間違いやすい統計解析2014

    • Author(s)
      千葉康敬
    • Journal Title

      近畿大学医学雑誌

      Volume: 39 Pages: 79-86

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Application of the mediation analysis approach to cancer prevention trials relating to cancer severity2014

    • Author(s)
      Chiba Y
    • Journal Title

      American Journal of Biostatistics

      Volume: 4 Pages: 45-51

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A note on the logistic regression model with a random coefficient to predict propensity scores2013

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Annals of Biometrics and Biostatistics

      Volume: 1 Pages: 1001-1001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kaplan-Meier curves for survivor causal effects with time-to-event outcomes2013

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Clinical Trials

      Volume: 10 Issue: 4 Pages: 515-521

    • DOI

      10.1177/1740774513483601

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simple method of measuring vaccine effects on infectiousness and contagion2013

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Open Journal of Statistics (Special Issue on Medical Studies in Statistics)

      Volume: 3(4A) Issue: 04 Pages: 7-15

    • DOI

      10.4236/ojs.2013.34a002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alternative monotonicity assumptions for improving bounds on natural direct effects2013

    • Author(s)
      Yasutaka Chiba, Masataka Taguri
    • Journal Title

      International Journal of Biostatistics

      Volume: 9 Issue: 2 Pages: 235-249

    • DOI

      10.1515/ijb-2012-0022

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conditional and unconditional infectiousness effects in vaccine trials2013

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Epidemiology

      Volume: 24 Issue: 2 Pages: 336-337

    • DOI

      10.1097/ede.0b013e31828261f5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The large sample bounds on the principal strata effect with application to a prostate cancer prevention trial2012

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      International Journal of Biostatistics

      Volume: 8(1) Issue: 1 Pages: 12-12

    • DOI

      10.1515/1557-4679.1365

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bounds on the complier average causal effect in randomized trials with noncompliance2012

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Statistics and Probability Letters

      Volume: 82 Issue: 7 Pages: 1352-1357

    • DOI

      10.1016/j.spl.2012.03.040

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A note on bounds for the causal infectiousness effect in vaccine trials2012

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Statistics and Probability Letters

      Volume: 82 Issue: 7 Pages: 1422-1429

    • DOI

      10.1016/j.spl.2012.04.002

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Instruments and bounds for causal effects under the monotonic selection assumption2012

    • Author(s)
      Masataka taguri
    • Journal Title

      International Journal of Biostatistics

      Volume: 8(1) Issue: 1 Pages: 24-24

    • DOI

      10.1515/1557-4679.1386

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simple method for sensitivity analysis of unmeasured confounding2012

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Journal of Biometrics and Biostatistics

      Volume: 3 Issue: 06

    • DOI

      10.4172/2155-6180.1000e113

    • Related Report
      2012 Research-status Report
  • [Journal Article] Estimation and sensitivity analysis of the survivor average causal effect under the monotonicity assumption2012

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Journal of Biometrics and Biostatistics

      Volume: 3 Issue: 07

    • DOI

      10.4172/2155-6180.1000e116

    • Related Report
      2012 Research-status Report
  • [Journal Article] Sensitivity analysis for unmeasured confounding ~2012

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Epidemiology

      Volume: 23 Issue: 1 Pages: 175-176

    • DOI

      10.1097/ede.0b013e31823b6409

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Marginal structural models for estimating ~2011

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Biometrical Journal

      Volume: 53 Issue: 6 Pages: 1025-1034

    • DOI

      10.1002/bimj.201100085

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] On the identification of the survivor average ~2011

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Journal of Biometrics and Biostatistics

      Volume: 2 Issue: 05

    • DOI

      10.4172/2155-6180.1000e104

    • Related Report
      2011 Research-status Report
  • [Presentation] 主要層別に基づく2×2分割表の正確検定2015

    • Author(s)
      千葉康敬
    • Organizer
      日本計量生物学会年会
    • Place of Presentation
      芝蘭会館(京都)
    • Year and Date
      2015-03-12 – 2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Attributable fractions and excess fractions with multiple exposure level: the relations and bounds2014

    • Author(s)
      Chiba Y
    • Organizer
      Joint Statistical Meeting
    • Place of Presentation
      Boston (U.S.A.)
    • Year and Date
      2014-08-03 – 2014-08-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Conditional and unconditional infectiousness effects in vaccine trials: the relation and estimation2013

    • Author(s)
      Yasutaka Chiba
    • Organizer
      Annual Meeting of the Society for Epidemiologic Research
    • Place of Presentation
      Boston (U.S.A.)
    • Related Report
      2013 Research-status Report
  • [Presentation] Simple techniques to assess the principal strata effect: estimation, sensitivity analysis, and bounds2013

    • Author(s)
      Yasutaka Chiba
    • Organizer
      Joint Statistical Meeting
    • Place of Presentation
      Montreal (Canada)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 周辺構造モデルを用いた主要層別効果の推定および感度解析2012

    • Author(s)
      上村夕香理
    • Organizer
      日本計量生物学会
    • Place of Presentation
      東京都立川市(統計数理研究所)
    • Related Report
      2012 Research-status Report
  • [Presentation] Bounds for the causal infectiousness effect in vaccine trials2012

    • Author(s)
      Yasutaka Chiba
    • Organizer
      Joint Statistical Meeting
    • Place of Presentation
      San Diego (U.S.A.)
    • Related Report
      2012 Research-status Report
  • [Presentation] The large sample bounds on the principal strata effect with application to a prostate cancer prevention trial2012

    • Author(s)
      Yasutaka Chiba
    • Organizer
      International Biometric Conference
    • Place of Presentation
      Kobe (Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] A principal stratification approach for evaluating natural direct and indirect effects in the presence of intermediate confounding2012

    • Author(s)
      Masataka Taguri
    • Organizer
      International Biometric Conference
    • Place of Presentation
      Kobe (Japan)
    • Related Report
      2012 Research-status Report
  • [Book] 医療統計力を鍛える!2015

    • Author(s)
      千葉康敬
    • Total Pages
      307
    • Publisher
      総合医学社
    • Related Report
      2014 Annual Research Report
  • [Book] Current Topics in Public Health (Chapter 3: Causal Inference with Intermediates: Simple Methods for Principal Strata Effects and Natural Direct Effects)2013

    • Author(s)
      Yasutaka Chiba, Etsuji Suzuki
    • Total Pages
      732
    • Publisher
      InTech
    • Related Report
      2013 Research-status Report
  • [Book] Vaccines - Benefits and Risks (Chapter 2: Assessing the Causal Infectiousness Effect in Vaccine Trials)2013

    • Author(s)
      Yasutaka Chiba, Masataka Taguri
    • Total Pages
      212
    • Publisher
      iConcept Press
    • Related Report
      2013 Research-status Report
  • [Book] Health Management2011

    • Author(s)
      Krzysztof Smigorski
    • Total Pages
      498
    • Publisher
      Intech
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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