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Molecular network design toward group-level decision making of cell populations

Research Project

Project/Area Number 23700350
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bioinformatics/Life informatics
Research InstitutionOsaka University

Principal Investigator

FUJIMOTO Koichi  大阪大学, 理学(系)研究科(研究院), 准教授 (60334306)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsモデル化 / 自己組織化 / 細胞 / 集団現象 / システム生物学 / 微生物 / 数理モデル / ネットワーク / クオラムセンシング / 集団的意思決定 / 細胞間コミュニケーション / 合成生物学 / 細胞集団 / 国際情報交換 / 遺伝子ネットワーク / 振動 / フィードバック
Outline of Final Research Achievements

Although the genetic circuits underlying state switching at the single-cell level are well understood, how such circuits work in concert among many cells to support the population-level switching of cellular behaviors is not fully explored. Experiments using microbial signaling systems show that group-level changes in cellular state occur in either a graded or an all-or-none fashion. We show that the type of group-level decision making used by populations is uniquely determined by a single dimensionless parameter that compares the quorum-signaling molecules accumulated within the cells with those secreted by the population. The role of the parameter is universal such that it not only applies to the autoinducing circuits but also to the more complex gene circuits involved in transmembrane receptor signaling and negative feedback. The design principle that we describe thus serves as the basis for the analysis and control of collective cellular decision making in general.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results) (of which Invited: 6 results) Book (1 results)

  • [Journal Article] A Design Principle of Group-level Decision Making in Cell Populations2013

    • Author(s)
      Koichi Fujimoto, Satoshi Sawai
    • Journal Title

      PLoS Comp. Biol.

      Volume: 9 (6) Issue: 6 Pages: e1003110-e1003110

    • DOI

      10.1371/journal.pcbi.1003110

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Robustness of Self-Organizing Chemoattractant Field Arising from Precise Pulse Induction of Its Breakdown Enzyme: A Single-Cell Level Analysis of PDE Expression in Dictyostelium.2013

    • Author(s)
      N. Masaki, K. Fujimoto, M.Honda-Kitahara, E. Hada and S. Sawai
    • Journal Title

      Biophys. J.

      Volume: 104 Issue: 5 Pages: 1191-1202

    • DOI

      10.1016/j.bpj.2013.01.023

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The collective oscillations in developing cells: Insights from simple systems.2011

    • Author(s)
      K. Kamino, K. Fujimoto and S. Sawai
    • Journal Title

      Dev. Growth Diff.

      Volume: 53 Issue: 4 Pages: 503-517

    • DOI

      10.1111/j.1440-169x.2011.01266.x

    • NAID

      10028273979

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Differential cell proliferation rate regulates epithelial tissue homeostasis during cell competition2014

    • Author(s)
      坪井有寿、藤本仰一
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dynamics of Multi-cellular Living Matter2014

    • Author(s)
      Koichi Fujimoto
    • Organizer
      Kavli IPMU & RIKEN iTHES & Osaka TSRP Symposium. Frontiers of Theoretical Science; MATTER, LIFE and COSMOS
    • Place of Presentation
      東京大学、千葉県柏市
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mechanical communications in cell societies 細胞の押し合いへし合いから探る 細胞社会の恒常性維持2014

    • Author(s)
      藤本仰一、坪井有寿、大澤志津江、井垣達吏
    • Organizer
      モデル生物丸ごと一匹学会
    • Place of Presentation
      大阪大学、大阪府豊中市
    • Year and Date
      2014-09-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mechanical properties that regulate differential cell division rate during cell competition2014

    • Author(s)
      Arisu Tsuboi, Shizue Ohsawa, Tatsushi Igaki and Koichi Fujimoto
    • Organizer
      Workshop on Mechanics and Growth of Tissues: From Development to Cancer
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Research-status Report
  • [Presentation] 細胞競合の数理モデル2013

    • Author(s)
      藤本仰一
    • Organizer
      第36回日本分子生物学会年会 ワークショップ
    • Place of Presentation
      神戸市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 細胞の集団的な意思決定の設計原理2013

    • Author(s)
      藤本仰一
    • Organizer
      定量生物学の会 第6回年会
    • Place of Presentation
      大阪大
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] A design principle of group-level decision making in cell populations.2013

    • Author(s)
      Koichi Fujimoto
    • Organizer
      2013 International Symposium on Nonlinear Theory and its Applications (NOLTA2013)
    • Place of Presentation
      Santa Fe, USA
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 細胞社会の集団的な意思決定のデザイン2013

    • Author(s)
      藤本仰一
    • Organizer
      生物リズム若手研究者の集い2013
    • Place of Presentation
      山梨県河口湖
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 細胞の集団的な応答の設計原理 1-双安定系2013

    • Author(s)
      藤本仰一
    • Organizer
      日本物理学会 秋季大会
    • Place of Presentation
      徳島大
    • Related Report
      2013 Research-status Report
  • [Presentation] 細胞の集団的な応答の設計原理 2 興奮振動系2013

    • Author(s)
      藤本仰一
    • Organizer
      日本物理学会 秋季大会
    • Place of Presentation
      徳島大
    • Related Report
      2013 Research-status Report
  • [Presentation] Design principle of group-level decision making in cell populations.2013

    • Author(s)
      Koichi Fujimoto
    • Organizer
      The 1st annual winter Q-bio coneference
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Synchronized Onset of Quorum Sensing Transition2012

    • Author(s)
      Koichi Fujimoto
    • Organizer
      Joint Meeting of The 45th Annual Meeting of JSDB and The 64th Annual Meeting of JSCB.
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Tuning collectivity in cell fate decision.2012

    • Author(s)
      Koichi Fujimoto
    • Organizer
      The 13th International Conference of Systems Biology
    • Place of Presentation
      Tronto, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞集団の応答を鋭敏にする細胞間相互作用の特徴2012

    • Author(s)
      藤本仰一
    • Organizer
      日本物理学会 第67回年次大会
    • Place of Presentation
      関西学院大学
    • Related Report
      2011 Research-status Report
  • [Presentation] cAMP振動を閾値的に開始し恒常的に維持する仕組み2011

    • Author(s)
      藤本仰一、澤井哲
    • Organizer
      第1回日本細胞性粘菌学会年会
    • Place of Presentation
      大阪大学
    • Related Report
      2011 Research-status Report
  • [Book] Emergence of Chemical Complexity.2013

    • Author(s)
      Koichi Fujimoto, Satoshi Sawai
    • Publisher
      World Scientific
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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