| Project/Area Number |
23700358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生体生命システム情報学 / 数値最適化 / パラメータ推定 / 動的システム / 記号計算 / 反応パラメータ推定 |
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| Research Abstract |
We proposed highly accurate parameter estimation method based on time-series data, by introducing constraints equations among estimated parameters derived rationally by symbolic computing technique to numerical optimization method. The performance of our proposed method of parameter accuracy is demonstrated by some representative model in biology, especially negative feed-back model which yields oscillations. The highly accurate parameter estimation method for dynamical systems we proposed will be the basis of systemically identification, analysis, control, and design of biological phenomena.
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